Human CD38 Recombinant | MyBioSource MBS553149 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human CD38 Recombinant

catalog :

MBS553149

quantity :

0.005 mg

price :

220 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS553149

products type :

Recombinant Protein

products full name :

Human CD38 Recombinant

products short name :

CD38

products name syn :

cd38; cd-38

other names :

ADP-ribosyl cyclase 1; ADP-ribosyl cyclase 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10

products gene name :

CD38

other gene names :

CD38; cADPr hydrolase 1

uniprot entry name :

CD38_HUMAN

host :

HEk293 Cells

sequence length :

300

purity :

>95%, as determined by SDS-PAGE and HPLC

form :

Recombinant CD38 is supplied as a 0.2 um filtered PBS solution, pH7.2.

storage stability :

Recombinant CD38, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months. Avoid repeated freeze/thaw cycles.

other info1 :

Domain: ADP ribosyl cyclase. Host Note: Optimized DNA sequence encoding Human extracellular domain of human CD38 including a C-terminal 6His tag was expressed in HEK293 cells.

other info2 :

Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug). Molecular Weight Note: Recombinant CD38 is a monomer protein consisting of 269 amino acid residue subunits, due to glycosylation migrates as an approximately 45 kDa protein on SDS-PAGE.

products categories :

Receptors CD

products description :

Human CD38 is a broadly expressed type II transmembrane glycoprotein of ~45 kDa in its monomeric form. This consists of a short intracytoplasmic (IC) tail, a transmembrane domain and a major extracellular domain (ECD) formed by 256 of the 300 constituent amino acids of the CD38 polypeptide.The CD38 ECD, where both receptor and enzymatic activities reside, harbours a 12 cysteine/6 disulfide signature common to the members of this family.

products references :

the ac133+ CD38 , but not the rhodamine-low, phenotype tracks ltc-ic and src function in human cord blood ex vivo expansion cultures . Blood, Jan 2010; 115: 257 - 260. CD38 -mediated ca2+ signaling contributes to angiotensin ii-induced activation of hepatic stellate cells: attenuation of hepatic fibrosis by CD38 ablation . J. Biol. Chem., Jan 2010; 285: 576 - 582. CD38 induces homing of chronic lymphocytic leukemia cells to the lymphoid organs through a functional interplay with cxcr4. . Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 2328. CD38 expression on cd34+ cells as a single flow cytometric parameter to distinguish myelodysplastic syndromes (mds) from non-clonal cytopenias. . Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 2783. CD38 cd49d are physically and functionally associated in b-cell chronic lymphocytic leukemia cells. . Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 357.

ncbi gi num :

38454326

ncbi acc num :

NP_001766.2

ncbi gb acc num :

NM_001775.2

uniprot acc num :

P28907

ncbi mol weight :

34,328 Da

ncbi pathways :

Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Metabolic Pathways (132956); Nicotinate And Nicotinamide Metabolism Pathway (83014); Nicotinate And Nicotinamide Metabolism Pathway (400); Pancreatic Secretion Pathway (169306); Pancreatic Secretion Pathway (169295); Salivary Secretion Pathway (153376)

ncbi summary :

The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

uniprot summary :

CD38: Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Belongs to the ADP-ribosyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 2.4.99.20; Lyase; Hydrolase; Apoptosis; EC 3.2.2.6; Membrane protein, integral; Cell surface; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cell cycle regulation. Chromosomal Location of Human Ortholog: 4p15. Cellular Component: cell surface; membrane; integral to membrane; plasma membrane; nucleus. Molecular Function: transferase activity; phosphorus-oxygen lyase activity; NAD+ nucleosidase activity; NAD(P)+ nucleosidase activity. Biological Process: response to drug; response to retinoic acid; metabolic process; positive regulation of transcription, DNA-dependent; positive regulation of insulin secretion; female pregnancy; signal transduction; positive regulation of cell growth; response to estradiol stimulus; B cell receptor signaling pathway; elevation of cytosolic calcium ion concentration; response to hydroperoxide; positive regulation of B cell proliferation; positive regulation of vasoconstriction; response to hypoxia; response to progesterone stimulus; negative regulation of transcription, DNA-dependent; negative regulation of bone resorption; negative regulation of apoptosis

size1 :

0.005 mg

price1 :

220 USD

size2 :

0.02 mg

price2 :

595

size3 :

0.1 mg

price3 :

2220

more info or order :

MyBioSource product webpage