This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
protein
product name :
Epstein-Barr Virus Early Antigen Recombinant
catalog :
MBS553147
quantity :
0.5 mg
price :
775 USD
product information
catalog number :
MBS553147
products type :
Recombinant Protein
products full name :
Epstein-Barr Virus Early Antigen Recombinant
products short name :
Epstein-Barr Virus Early Antigen
products name syn :
ea; early antigen; ebv; epstein barr
other names :
BMRF1; DNA polymerase processivity factor BMRF1; Early antigen protein D; EA-D; Polymerase accessory subunit
products gene name :
EBV EA
other gene names :
EA-D; EA-D
uniprot entry name :
EAD_EBVB9
host :
E Coli
sequence length :
404
purity :
>90%, as determined by SDS-PAGE.
form :
50mM Tris-HCl pH 8, 10mM glutathione, 60mM NaCl and 50% Glycerol.
storage stability :
This protein can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
app notes :
Recombinant human EBV EA antigen is suitable for ELISA and Western blots, excellent antigen for detection of EBV with minimal specificity problems.
other info1 :
Host Note: DNA sequence encoding immunodominant fragment of Epstein-Barr Early Antigen expressed in Escherichia Coli.
other info2 :
Molecular Weight Note: Recombinant EBV EA encodes the C terminal immunodominant sequence (306-390) of the Epstein-Barr Virus Early Antigen protein D BMRF1. Recombinant EBV EA contains an N terminal GST purification tag and migrates as an approximately 36 kDa protein under non-reducing conditions conditions in SDS-PAGE.
products categories :
Viral Antigens
ncbi gi num :
82503215
ncbi acc num :
YP_401657.1
ncbi gb acc num :
NC_007605.1
uniprot acc num :
P03191
ncbi mol weight :
43,374 Da
uniprot summary :
Function: Plays an essential role in the viral lytic DNA replication by acting as the polymerase accessory subunit. Stimulates the viral DNA polymerase activity and appears to function with it as a holoenzyme. Increases the processivity of the viral polymerase, probably by acting as a sliding clamp that prevents dissociation of the polymerase from the active template. In addition, BMRF1 transcriptionally activates the early BHLF1 promoter. Ref.4 Ref.9. Subunit structure: Homooligomerizes and adopts an oligomeric ring-shaped structure composed of 6 subunits. Forms a complex with the DNA-binding protein BALF2, the DNA polymerase subunit BALF5, and the alkaline exonuclease BGLF5. Interacts with BZLF1; this interaction may inhibit BZLF1-induced transcription of the BMRF1 promoter. Ref.4 Ref.5 Ref.6. Subcellular location: Virion tegument. Host nucleus. Note: BMRF1 shows homogeneous, not dot-like, distribution in the replication compartments, which coincides with the newly synthesized viral DNA. Ref.7 Ref.8. Post-translational modification: Phosphorylated by the viral BGLF4 kinase. Ref.10. Sequence similarities: Belongs to the herpesviridae DNA polymerase accessory subunit family.
size :
0.5 mg
price :
775 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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