Human IL-2RB Recombinant (CD122) | MyBioSource MBS553138 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human IL-2RB Recombinant (CD122)

catalog :

MBS553138

quantity :

0.005 mg

price :

220 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS553138

products type :

Recombinant Protein

products full name :

Human IL-2RB Recombinant (CD122)

products short name :

IL-2RB (CD122)

products name syn :

Human CD122 Recombinant (IL2RB) ; CD122; IL2RB; il-2Rb; il2R

other names :

interleukin-2 receptor subunit beta; Interleukin-2 receptor subunit beta; High affinity IL-2 receptor subunit beta; p70-75

products gene name :

CD122

products gene name syn :

IL-2R

other gene names :

IL2RB; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; p75

uniprot entry name :

IL2RB_HUMAN

host :

HEk293 Cells

sequence length :

551

purity :

>97%, as determined by SDS-PAGE and HPLC

form :

Recombinant IL-2RB is supplied as a lyophilized 0.2 um filtered PBS solution, pH7.2.

storage stability :

Recombinant IL2RB, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months. Avoid repeated freeze/thaw cycles.

other info1 :

Domain: Extracellular. Host Note: Optimized DNA sequence encoding extracellular domain of human Interleukin-2 receptor beta subunit including an Fc tag was expressed in HEK293 cells.

other info2 :

Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug). Molecular Weight Note: Recombinant IL2RB is a monomer protein consisting of 451 amino acid residue subunits, due to glycosylation migrates as an approximately 60kDa protein on SDS-PAGE.

products categories :

Receptors CD

products references :

late expression of granulysin by microbicidal cd4+ t cells requires pi3k- and stat5-dependent expression of il-2r that is defective in hiv-infected patients . J. Immunol., Jun 2008; 180: 7221 - 7229. quantitative assessment concerning the contribution of il-2r for superantigen-mediated t cell responses in vivo . Int. Immunol., Apr 2006; 18: 565 - 572. il-2 responsiveness of cd4 and cd8 lymphocytes: further investigations with human il-2r transgenic mice . Int. Immunol., Aug 2005; 17: 1093 - 1102. endogenous il-15 sustains recruitment of il-2r and common and il-2-mediated chemokine production in normal and inflamed human gingival fibroblasts . J. Immunol., Oct 2004; 173: 5180 - 5188. t cell proliferation due to 4-1bb is dependent upon il-2r and results in functional expression of ctla-4 . AACR Meeting Abstracts, Mar 2004; 2004: 1087.

ncbi gi num :

4504665

ncbi acc num :

NP_000869.1

ncbi gb acc num :

NM_000878.3

uniprot acc num :

P14784

ncbi mol weight :

61,117 Da

ncbi pathways :

Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Downstream Signaling In Naive CD8+ T Cells Pathway (138018); Endocytosis Pathway (102279); Endocytosis Pathway (102181); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); IL-2 Signaling Pathway (198885); IL-5 Signaling Pathway (198770)

ncbi summary :

The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008]

uniprot summary :

IL2RB: Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I. Belongs to the type I cytokine receptor family. Type 4 subfamily. Protein type: Receptor, cytokine; Membrane protein, integral. Chromosomal Location of Human Ortholog: 22q13.1. Cellular Component: membrane; integral to plasma membrane; plasma membrane; external side of plasma membrane. Molecular Function: interleukin-2 receptor activity; interleukin-2 binding. Biological Process: viral reproduction; cytokine and chemokine mediated signaling pathway; protein complex assembly; signal transduction; negative regulation of apoptosis

size1 :

0.005 mg

price1 :

220 USD

size2 :

0.02 mg

price2 :

540

size3 :

0.1 mg

price3 :

1915

more info or order :

MyBioSource product webpage