Human IL-6 Receptor Recombinant (IL-6R) | MyBioSource MBS553132 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human IL-6 Receptor Recombinant (IL-6R)

catalog :

MBS553132

quantity :

0.01 mg

price :

220 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS553132

products type :

Recombinant Protein

products full name :

Human IL-6 Receptor Recombinant (IL-6R)

products short name :

IL-6 Receptor (IL-6R)

products name syn :

Human CD126 Recombinant (IL6 Receptor) ; cd-126 IL6R; CD126; IL-6R-1; IL-6R-alpha; IL6RA; MGC104991; IL6 Receptor

other names :

interleukin-6 receptor subunit alpha isoform 1; Interleukin-6 receptor subunit alpha; IL-6R 1; Membrane glycoprotein 80

products gene name :

CD126

other gene names :

IL6R; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; gp80

uniprot entry name :

IL6RA_HUMAN

host :

HEk293 Cells

sequence length :

468

purity :

>97%, as determined by SDS-PAGE and HPLC

form :

Recombinant Human Interleukin-6 receptor (CD126) is supplied as a 0.2 um filtered PBS solution, pH7.2.

storage stability :

Recombinant human IL-6R, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months. Avoid repeated freeze/thaw cycles.

other info1 :

Domain: Ig-like C2. Host Note: Optimized DNA sequence encoding extracellular domain of human IL-6 receptor (CD126) including a C-terminal 6His tag was expressed in HEK293 cells.

other info2 :

Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug). Molecular Weight Note: Recombinant IL-6 receptor (CD126) is a monomer protein consisting of 357 amino acid residue subunits, due to glycosylation migrates as an approximately 60-65 kDa protein on SDS-PAGE.

products categories :

Receptors CD

products description :

The effects of IL-6 are mediated by a functional IL- 6 receptor (IL-6R), which consists in a heterodimer formed by an IL-6-binding chain (IL-6R ) and a signal- transducing subunit, gp130 or IL-6R . Binding of IL-6 to the IL-6R induces homodimerization of two gp130 molecules, leading to intracellular signals.

products references :

anti-inflammatory effect of IL-6 receptor blockade on experimental corneal alkali burn . Invest. Ophthalmol. Vis. Sci., Mar 2012; 53: 4206. exposure-response relationship of tocilizumab, an anti IL-6 receptor monoclonal antibody, in a large population of patients with rheumatoid arthritis . J. Clin. Pharmacol., Feb 2012; 10.1177/0091270012437585. impact of IL-6 receptor inhibition on human memory b cells in vivo: impaired somatic hypermutation in preswitch memory b cells and modulation of mutational targeting in memory b cells . Ann Rheum Dis, Aug 2011; 70: 1507 - 1510. species specificity of adam10 and adam17 proteins in interleukin-6 (il-6) trans-signaling and novel role of adam10 in inducible IL-6 receptor shedding . J. Biol. Chem., Apr 2011; 286: 14804 - 14811. anti- IL-6 receptor antibody (tocilizumab) : a b cell targeting therapy . Ann Rheum Dis, Mar 2011; 70: A57 - A58.

ncbi gi num :

4504673

ncbi acc num :

NP_000556.1

ncbi gb acc num :

NM_000565.3

uniprot acc num :

P08887

ncbi mol weight :

51,548 Da

ncbi pathways :

Cytokine Signaling In Immune System Pathway 366171!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Hematopoietic Cell Lineage Pathway 83078!!Hematopoietic Cell Lineage Pathway 489!!IL-6 Signaling Pathway 198864!!IL6-mediated Signaling Events Pathway 137932!!Immune System Pathway 106386!!Interleukin-6 Signaling Pathway 205111!!Jak-STAT Signaling Pathway 83077

uniprot summary :

Function: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Ref.13 Ref.14Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Ref.13 Ref.14. Subunit structure: Hexamer of two molecules each of IL6, IL6R and IL6ST. Subcellular location: Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein Ref.11 Ref.14. Isoform 2: Secreted Ref.11 Ref.14. Tissue specificity: Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum. Domain: The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain.The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. Post-translational modification: A short soluble form may also be released from the membrane by proteolysis. Polymorphism: Genetic variations in IL6R determine soluble IL6R serum levels [. MIM:614689].Genetic variations in IL6R define the IL6 serum level quantitative trait locus [. MIM:614752]. Sequence similarities: Belongs to the type I cytokine receptor family. Type 3 subfamily.Contains 1 fibronectin type-III domain.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

size :

0.01 mg

price :

220 USD

more info or order :

MyBioSource product webpage