protein

Human IL-1 receptor 1 Recombinant (CD121a)

MBS553050

0.02 mg

220 USD

Recombinant Protein

Human IL-1 receptor 1 Recombinant (CD121a)

IL-1 receptor 1 (CD121a)

Human CD121a Recombinant (IL1R1) ; CD121A; D2S1473; IL-1R1; IL1R1; IL1RA; P80; IL1R1

interleukin-1 receptor type 1; Interleukin-1 receptor type 1; CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha; Interleukin-1 receptor type I; p80

CD121a

IL-1R1

IL1R1; IL1R; IL1RA; IL1RT1; IL-1R-1; IL-1RT-1; IL-1RT1; IL-1R-alpha; mIL-1R1; mIL-1RI; sIL-1R1; sIL-1RI

IL1R1_HUMAN

HEk293 Cells

569

>97%, as determined by SDS-PAGE and HPLC

Recombinant Human IL-1R (CD121a) is lyophilized from 0.2 um filtered PBS solution, pH7.2, 5% Trehalose.

Recombinant Human IL1R1 can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months. Avoid repeated freeze/thaw cycles.

Domain: Ig-like C2. Host Note: Optimized DNA sequence encoding Human extracellular domain of human IL-1 receptor including a C-terminal Fc tag was expressed in HEK293 cells.

Molecular Weight Note: Recombinant IL-R1 (CD121a) is a homodimer protein consisting of 327 amino acid residue subunits, due to glycosylation migrates as an approximately 55-60 kDa protein on SDS-PAGE.

Receptors CD

pellino 2 is critical for toll-like receptor/interleukin-1 receptor (tlr/ IL-1R ) -mediated post-transcriptional control . J. Biol. Chem., Jul 2012; 287: 25686 - 25695. role of toll interleukin-1 receptor ( IL-1R ) 8, a negative regulator of IL-1R /toll-like receptor signaling, in resistance to acute pseudomonas aeruginosa lung infection . Infect. Immun., Jan 2012; 80: 100 - 109. IL-1R associated kinase-1 mediates protein kinase c-induced il-1 production in monocytes . J. Immunol., Sep 2011; 187: 2632 - 2645. effect of mitomycin c on IL-1R expression, il-1 related hepatocyte growth factor secretion and corneal epithelial cell migration . Invest. Ophthalmol. Vis. Sci., Mar 2010; 51: 1389 - 1396. mycobacterium bovis bacillus calmette-gu rin vaccination mobilizes innate myeloid-derived suppressor cells restraining in vivo t cell priming via IL-1R dependent nitric oxide production . J. Immunol., Feb 2010; 184: 2038 - 2047.

4504659

NP_000868.1

NM_000877.2

P14778

65,402 Da

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Function: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Ref.11. Subunit structure: The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1. Ref.9 Ref.10. Subcellular location: Membrane; Single-pass type I membrane protein. Cell membrane . Probable. Secreted Ref.7. Post-translational modification: A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).Rapidely phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1. Ref.10. Sequence similarities: Belongs to the interleukin-1 receptor family.Contains 3 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 TIR domain.

0.02 mg

220 USD