Human CD32a Recombinant (FcgRIIa) | MyBioSource MBS553040 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human CD32a Recombinant (FcgRIIa)

catalog :

MBS553040

quantity :

0.02 mg

price :

220 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS553040

products type :

Recombinant Protein

products full name :

Human CD32a Recombinant (FcgRIIa)

products short name :

CD32a (FcgRIIa)

products name syn :

Human CD32a Recombinant (Fcg RIIa) ; Human CD32a Recombinant (Fcgamma RIIa) ; cd32; cd-32

other names :

low affinity immunoglobulin gamma Fc region receptor II-a isoform 1; Low affinity immunoglobulin gamma Fc region receptor II-a; CDw32; Fc-gamma RII-a

products gene name :

CD32

other gene names :

FCGR2A; CD32; FCG2; FCGR2A1; IGFR2; IgG Fc receptor II-a; Fc-gamma-RIIa; FcRII-a

uniprot entry name :

FCG2A_HUMAN

host :

HEk293 Cells

sequence length :

317

purity :

>95%, as determined by SDS-PAGE and HPLC

form :

Recombinant CD32a is supplied as a lyophilized 0.2 um filtered PBS solution, pH7.2.

storage stability :

Lyophilized CD32a, as supplied, should be stored at -20 degree C to -70 degree C. Upon resconstitution, working aliquots may be stored at 2-8 degree C for one month, or six months at -20 degree C without detectable loss of activity. It is recommended to add 0.1% BSA for long term storage.

other info1 :

Domain: Ig-like C2. Host Note: Optimized DNA sequence encoding Human extracellular domain of human CD32a including a C-terminal 6His tag was expressed in HEK293 cells.

other info2 :

Biological Activity: 1 ug of immobilized CD32a was tested to bind human IgG2 in a range of 10-200ng/ml. Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug). Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. Molecular Weight Note: Recombinant CD32a is a monomer protein consisting of 192 amino acid residue subunits, due to glycosylation migrates as an approximately 25 kDa protein on SDS-PAGE.

products categories :

Receptors CD

products description :

Fc RIIA is expressed on cells ofboth myeloid and lymphoid lineages as well as on cells of non- hematopoietic origin.Associated with an ITAM (immunoreceptor tyrosine-based activation motif) -bearing adapter subunit,FcR ,CD32a (Fc RIIA) d elivers an activating signal upon ligand binding,and results in the initiation of inflammatory responses including cytolysis,phagocytosis,degra nulation and cytokine production.The responses can be modulated by signals from the coexpressed inhibitory receptors such as Fc RIIB,and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.

products references :

dynamics of the interaction of human igg subtype immune complexes with cells expressing r and h allelic forms of a low-affinity fc receptor CD32a . J. Immunol., Dec 2009; 183: 8216 - 8224. association of fcriia ( CD32a ) with lipid rafts regulates ligand binding activity . J. Immunol., Jun 2009; 182: 8026 - 8036. transgenic expression of human platelet fcriia ( CD32a ) in mice does not affect the thrombocytopenia associated with wasp deficiency. . Blood (ASH Annual Meeting Abstracts), Nov 2006; 108: 1106.

ncbi gi num :

210031822

ncbi acc num :

NP_001129691.1

ncbi gb acc num :

NM_001136219.1

uniprot acc num :

P12318

ncbi mol weight :

35,001 Da

ncbi pathways :

Fc Gamma R-mediated Phagocytosis Pathway (114228); Fc Gamma R-mediated Phagocytosis Pathway (106590); Leishmaniasis Pathway (144181); Leishmaniasis Pathway (144028); Osteoclast Differentiation Pathway (193147); Osteoclast Differentiation Pathway (193096); Phagosome Pathway (153910); Phagosome Pathway (153859); Signaling Events Mediated By PTP1B Pathway (138017); Staphylococcus Aureus Infection Pathway (172846)

ncbi summary :

This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]

uniprot summary :

FCGR2A: low affinity receptor for the Fc region of IgGs. Binding to IgG initiates cellular responses against pathogens and soluble antigens. A type I membrane protein found on monocytes, neutrophils and platelets. SHP-1 associates with this protein to modulate signaling events in myeloid cells. Protein type: Cell surface; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1q23. Cellular Component: integral to membrane; plasma membrane. Molecular Function: IgG binding. Biological Process: innate immune response. Disease: Systemic Lupus Erythematosus; Malaria, Susceptibility To

size1 :

0.02 mg

price1 :

220 USD

size2 :

0.1 mg

price2 :

540

size3 :

0.5 mg

price3 :

2220

more info or order :

MyBioSource product webpage