Human CD106 Recombinant (VCAM1) | MyBioSource MBS553035 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human CD106 Recombinant (VCAM1)

catalog :

MBS553035

quantity :

0.02 mg

price :

220 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS553035

products type :

Recombinant Protein

products full name :

Human CD106 Recombinant (VCAM1)

products short name :

CD106 (VCAM1)

products name syn :

Human CD106 Recombinant (VCAM1) ; cd-106 VCAM1; CD106; DKFZp779G2333; INCAM-100; MGC99561

other names :

vascular cell adhesion protein 1 isoform a; Vascular cell adhesion protein 1; INCAM-100

products gene name :

CD106

other gene names :

VCAM1; L1CAM; V-CAM 1; VCAM-1

uniprot entry name :

VCAM1_HUMAN

host :

HEk293 Cells

sequence length :

739

purity :

>95%, as determined by SDS-PAGE and HPLC

form :

Recombinant CD106 is supplied as a 0.2 um filtered PBS solution, pH7.2.

storage stability :

Recombinant CD106, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months. Avoid repeated freeze/thaw cycles.

other info1 :

Domain: Ig-like C2. Host Note: Optimized DNA sequence encoding Human extracellular domain of human CD106 including a C-terminal 6His tag was expressed in HEK293 cells.

other info2 :

Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug). Molecular Weight Note: Recombinant CD106 (VCAM1) is a monomer protein consisting of 689 amino acid residue subunits, due to glycosylation migrates as an approximately 110 kDa protein on SDS-PAGE. Biological Activity: The activity of recombinant VCAM1 was tested by immobilized recombinant CD106 (10ug/ml) ability to support adhesion of U937 human histiocytic lymphoma cells (5X10^4 cells/well), 70% will adhere after 60 minutes at 37 degree C.

products categories :

Receptors CD

products references :

differential engagement of modules 1 and 4 of vascular cell adhesion molecule-1 ( CD106 ) by integrins 41 (cd49d/29) and m2 (cd11b/18) of eosinophils . J. Biol. Chem., Oct 2006; 281: 32175 - 32187. novel expression of vascular cell adhesion molecule-1 ( CD106 ) by squamous epithelium in experimental acute graft-versus-host disease . Am. J. Pathol., Sep 2002; 161: 763 - 770. vascular cell adhesion molecule-1 ( CD106 ) is cleaved by neutrophil proteases in the bone marrow following hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor . Blood, Sep 2001; 98: 1289 - 1297. rheumatoid arthritis synovial stromal cells inhibit apoptosis and up-regulate bcl-xl expression by b cells in a cd49/cd29- CD106 -dependent mechanism . J. Immunol., Jan 2000; 164: 1110 - 1116. thrombin-activated human endothelial cells support monocyte adhesion in vitro following expression of intercellular adhesion molecule-1 (icam-1; cd54) and vascular cell adhesion molecule-1 (vcam-1; CD106 ) . Blood, Aug 1998; 92: 1259 - 1267.

ncbi gi num :

4507875

ncbi acc num :

NP_001069.1

ncbi gb acc num :

NM_001078.3

uniprot acc num :

P19320

ncbi mol weight :

81,276 Da

ncbi pathways :

Adaptive Immunity Signaling Pathway (366160); African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cellular Roles Of Anthrax Toxin Pathway (138076); Cytokine Signaling In Immune System Pathway (366171); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); Immune System Pathway (106386)

ncbi summary :

This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]

uniprot summary :

VCAM1: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion. Chromosomal Location of Human Ortholog: 1p32-p31. Cellular Component: Golgi apparatus; extracellular space; cell surface; microvillus; endoplasmic reticulum; early endosome; integral to membrane; apical part of cell; plasma membrane; podosome; sarcolemma; external side of plasma membrane; filopodium. Molecular Function: amine oxidase activity; integrin binding; cell adhesion molecule binding. Biological Process: response to nicotine; extracellular matrix organization and biogenesis; regulation of immune response; chronic inflammatory response; viral reproduction; cell-matrix adhesion; heart development; cytokine and chemokine mediated signaling pathway; response to lipopolysaccharide; heterophilic cell adhesion; leukocyte adhesion; response to ethanol; response to zinc ion; B cell differentiation; membrane to membrane docking; response to hypoxia; positive regulation of T cell proliferation; response to ionizing radiation; amine metabolic process; cell adhesion; leukocyte tethering or rolling; acute inflammatory response; response to nutrient; aging

size1 :

0.02 mg

price1 :

220 USD

size2 :

0.1 mg

price2 :

540

size3 :

0.5 mg

price3 :

1915

more info or order :

MyBioSource product webpage