Human CD66c Recombinant (CEACAM6) | MyBioSource MBS553010 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human CD66c Recombinant (CEACAM6)

catalog :

MBS553010

quantity :

0.02 mg

price :

220 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS553010

products type :

Recombinant Protein

products full name :

Human CD66c Recombinant (CEACAM6)

products short name :

CD66c (CEACAM6)

products name syn :

Human CD66c Recombinant (CEACAM6) ; CEACAM6 CD66c CEAL NCA cd66

other names :

carcinoembryonic antigen-related cell adhesion molecule 5 preproprotein; Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen; CEA; Meconium antigen 100

products gene name :

CD66

other gene names :

CEACAM5; CEA; CEA

uniprot entry name :

CEAM5_HUMAN

host :

HEk293 Cells

sequence length :

702

purity :

>95%, as determined by SDS-PAGE and HPLC

form :

Recombinant human CD66c is supplied as a 0.2 um filtered PBS solution, pH7.2.

storage stability :

Recombinant CD66c, as supplied, can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C to -70 degree C for twelve months. Avoid repeated freeze/thaw cycles.

other info1 :

Domain: Ig-like C2. Host Note: Optimized DNA sequence encoding Human extracellular domain of human CD66c was fused with the C-terminal polyhistidine-tagged at the C-terminus was expressed in HEK293 cells.

other info2 :

Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug). Molecular Weight Note: Recombinant Human CD66c is a monomer protein.The reduced monomer consists of 547 amino acids and has a predicted molecular mass of approx 70kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of CD66c monomer is approximately 160-180 kDa due to glycosylation.

products categories :

Receptors CD

products description :

CEACAM6 (CD66c) and CEACAM8 (CD66b) are cell-adhesion proteins onneutrophils that belong to the human carcinoembryonic antigen (CEA) family. CEACAM6 reveals homophilic adhesion and heterophilic adhesionto other CEACAM family antigens including CEACAM8, CEACAM1, and CEA,whereas CEACAM8 exhibits only heterophilic adhesion to CEACAM6

products references :

influenza a virus neuraminidase protein enhances cell survival through interaction with carcinoembryonic antigen-related cell adhesion molecule 6 ( CEACAM6 ) protein . J. Biol. Chem., Apr 2012; 287: 15109 - 15117. significance of CEACAM6 expression in biliary tract carcinoma. . ASCO Meeting Abstracts, Feb 2012; 30: 207. identification of CEACAM6 as an intermediate filament-associated protein expressed in sertoli cells of rat testis . Biol Reprod, Nov 2011; 85: 924 - 933. protein expression analysis of alcam and CEACAM6 in breast cancer metastases reveals significantly increased alcam expression in metastases of the skin . J. Clin. Pathol., Feb 2011; 64: 146 - 152. design and activity of a murine and humanized anti- CEACAM6 single-chain variable fragment in the treatment of pancreatic cancer . Cancer Res., Mar 2009; 69: 1933 - 1940.

ncbi gi num :

98986445

ncbi acc num :

NP_004354.2

ncbi gb acc num :

NM_004363.2

uniprot acc num :

P06731

ncbi mol weight :

76,795 Da

ncbi summary :

This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

uniprot summary :

CEACAM5: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins. Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily. CEA family. Protein type: Immunoglobulin superfamily; Membrane protein, integral; Membrane protein, GPI anchor. Chromosomal Location of Human Ortholog: 19q13.1-q13.2. Cellular Component: basolateral plasma membrane; integral to plasma membrane. Molecular Function: identical protein binding; protein homodimerization activity. Biological Process: homotypic cell-cell adhesion; negative regulation of apoptosis

size1 :

0.02 mg

price1 :

220 USD

size2 :

0.1 mg

price2 :

595

size3 :

0.5 mg

price3 :

2220

more info or order :

MyBioSource product webpage