catalog number :
MBS551127
products full name :
Human 4-1BB Affinity Purified Polyclonal
products short name :
4-1BB
products name syn :
RAA05020; polyclonal; 4-1BB
other names :
4-1BB; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily member 9; CD137 antigen; T cell antigen ILA; T-cell antigen ILA; 4-1BB ligand receptor; homolog of mouse 4-1BB; receptor protein 4-1BB; T-cell antigen 4-1BB homolog; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; tumor necrosis factor receptor superfamily, member 9; 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA
products gene name :
4-1BB
other gene names :
TNFRSF9; TNFRSF9; ILA; 4-1BB; CD137; CDw137; CD137; ILA
uniprot entry name :
TNR9_HUMAN
storage stability :
This antibody can be stored in working aliquots at 2C - 8C for one month without detectable loss of activity. The antibody is stable for at least 1 year from date of receipt at -20C. Avoid repeated freeze/thaw cycles.
app notes :
Western Blot Concentration: 0.1-0.2 ug/ml. Western Blot Limit: 1 ng/lane. ELISA Concentration: 0.1-0.2 ug/ml. ELISA Limit: 5 pg/well
products categories :
Antigen affinity polyclonals
ncbi acc num :
AAA53133.1
ncbi mol weight :
27,899 Da
ncbi pathways :
Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Downstream Signaling In Naive CD8+ T Cells Pathway 138018!!TCR Signaling Pathway 198862
ncbi summary :
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]
uniprot summary :
Function: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation. Subunit structure: Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1. Ref.9 Ref.10 Ref.11. Subcellular location: Membrane; Single-pass type I membrane protein. Tissue specificity: Expressed on the surface of activated T-cells. Sequence similarities: Contains 4 TNFR-Cys repeats.