catalog number :
MBS551035
products full name :
Rabbit anti Human CD66c (CEACAM6) Polyclonal
products short name :
CD66c (CEACAM6)
products name syn :
Rabbit anti Human CD66c (CEACAM6) Polyclonal purified; cd66c; cd-66c; cd-66; cd66; CEACAM6; polyclonal; PAb
other names :
carcinoembryonic antigen-related cell adhesion molecule 5 preproprotein; Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen; CEA; Meconium antigen 100
products gene name :
CD66
other gene names :
CEACAM5; CEA; CEA
uniprot entry name :
CEAM5_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Serum IgG fraction was purified by Protein A affinity chromatography.
form :
0.2 um filtered solution in PBS with 5% trehalose.
storage stability :
The lyophilized antibody is stable for at least 1 year from date of receipt at -20 degree C. Upon reconstitution, this antibody can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months without detectable loss of activity. Avoid repeated freeze/thaw cycles. Shelf Life: >12 months
tested application :
ELISA (EIA)
app notes :
ELISA: Use at a concentration range of 0.5-1ug/ml. The detection limit for CEACAM6 is approximately 0.16 ng/well.
other info1 :
Source Note: Polyclonal CD66c antibody was produced from sera of rabbits immunized with recombinant human CD66c.
other info2 :
Reconstitution: A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers.
products categories :
Polyclonal
ncbi acc num :
NP_004354.2
ncbi gb acc num :
NM_004363.2
ncbi mol weight :
76,795 Da
ncbi summary :
This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
uniprot summary :
CEACAM5: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins. Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily. CEA family. Protein type: Membrane protein, integral; Immunoglobulin superfamily; Membrane protein, GPI anchor. Chromosomal Location of Human Ortholog: 19q13.1-q13.2. Cellular Component: integral to plasma membrane; basolateral plasma membrane. Molecular Function: identical protein binding; protein homodimerization activity. Biological Process: homotypic cell-cell adhesion; negative regulation of apoptosis