Rabbit anti FGF-10 Polyclonal | MyBioSource MBS551017 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti FGF-10 Polyclonal

catalog :

MBS551017

quantity :

0.1 mg

price :

280 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS551017

products type :

Antibody

products full name :

Rabbit anti FGF-10 Polyclonal

products short name :

FGF-10

products name syn :

Rabbit anti FGF-10 Polyclonal purified; FGF10; fgf-10; fibroblast growth factor; kgf2; kgf-2; polyclonal; PAb

other names :

fibroblast growth factor 10; Fibroblast growth factor 10; Keratinocyte growth factor 2

products gene name :

FGF-10

other gene names :

FGF10; FGF-10

uniprot entry name :

FGF10_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

208

purity :

Serum IgG fraction was purified by Protein G affinity chromatography.

form :

Lyophilized from sterile filtered PBS solution at a concentration of 1mg/ml.

storage stability :

The lyophilized antibody is stable for at least 1 year from date of receipt at -20 degree C. Upon reconstitution, this antibody can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months without detectable loss of activity. Avoid repeated freeze/thaw cycles. Shelf Life: >12 months

tested application :

Western Blot (WB), IHC (Immunohistochemistry), ELISA (EIA)

app notes :

ELISA: Use at a concentration range of 1-2ug/ml. Western blot:A suitable range of concentrations of this antibody for WB detection is 2-10 ug/ml. IHC: A suitable range of concentrations of this antibody for IHC is 2-10 ug/ml.

other info1 :

Source Note: Polyclonal FGF-10 antibody was produced from sera of rabbits immunized with synthetic protein containing synthetic protein containing FGF-10 antigenic determinants.

other info2 :

Reconstitution: A quick spin of the vial followed by reconstitution in sterile 10mM PBS pH 7.4.

products categories :

Polyclonal

products description :

FGF-10 is involved in the initial budding as well as the continuous outgrowth of vertebrate limbs, FGF10 mRNA is expressed preferentially in neurons but not in glial cells and may have a distinct role in the brain.

products references :

a new FGF10 mutation in the mouse leads to atrophy of the harderian gland and slit-eye phenotype in heterozygotes: a novel model for dry-eye disease? . Invest. Ophthalmol. Vis. Sci., Sep 2009; 50: 4311 - 4318. the homeodomain transcription factor barx2 is required for normal lacrimal gland development and cooperates with FGF10 in regulation of branching morphogenesis . Invest. Ophthalmol. Vis. Sci., Apr 2009; 50: 4236. progesterone regulates FGF10 , met, igfbp1, and igfbp3 in the endometrium of the ovine uterus . Biol Reprod, Dec 2008; 79: 1226 - 1236. cystic adenomatoid malformations are induced by localized FGF10 overexpression in fetal rat lung . Am. J. Respir. Cell Mol. Biol., Sep 2008; 39: 346 - 355. specific heparan sulfate structures modulate FGF10 -mediated submandibular gland epithelial morphogenesis and differentiation . J. Biol. Chem., Apr 2008; 283: 9308 - 9317.

ncbi gi num :

4758360

ncbi acc num :

NP_004456.1

ncbi gb acc num :

NM_004465.1

uniprot acc num :

O15520

ncbi mol weight :

23,436 Da

ncbi pathways :

Downstream Signaling Of Activated FGFR Pathway 160957!!FGFR Ligand Binding And Activation Pathway 106344!!FGFR1 Ligand Binding And Activation Pathway 106345!!FGFR1b Ligand Binding And Activation Pathway 106346!!FGFR2 Ligand Binding And Activation Pathway 106349!!FGFR2b Ligand Binding And Activation Pathway 106350!!FRS2-mediated Cascade Pathway 160958!!Heart Development Pathway 198802!!IRS-mediated Signalling Pathway 106426!!IRS-related Events Pathway 106424

uniprot summary :

Function: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. May play a role in wound healing. Ref.8. Subunit structure: Interacts with FGFR1 and FGFR2. Interacts with FGFBP1. Ref.7 Ref.8. Subcellular location: Secreted . Potential. Involvement in disease: Aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]: A rare condition characterized by dry conjunctival mucosae, irritable eyes, epiphora (constant tearing), and xerostomia (dryness of the mouth), which increases risk of dental erosion, dental caries, periodontal disease, and oral infections. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular, and sublingual glands and absence of the lacrimal puncta.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.11Lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]: An autosomal dominant ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. Lacrimo-auriculo-dento-digital syndrome is characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.12 Ref.13. Sequence similarities: Belongs to the heparin-binding growth factors family.

size :

0.1 mg

price :

280 USD

more info or order :

MyBioSource product webpage