Rabbit anti Mouse CD32b (FCGR2B) Polyclonal | MyBioSource MBS551009 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti Mouse CD32b (FCGR2B) Polyclonal

catalog :

MBS551009

quantity :

0.1 mg

price :

280 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS551009

products type :

Antibody

products full name :

Rabbit anti Mouse CD32b (FCGR2B) Polyclonal

products short name :

Mouse CD32b (FCGR2B)

products name syn :

Rabbit anti Mouse CD32b (FCGR2B) Polyclonal purified; fcgr2b; cd32b; cd-32bpolyclonal; PAb

other names :

low affinity immunoglobulin gamma Fc region receptor II-b isoform 2; Low affinity immunoglobulin gamma Fc region receptor II-b; CDw32; Fc-gamma RII-b

products gene name :

CD32

other gene names :

FCGR2B; CD32; FCG2; IGFR2; IgG Fc receptor II-b; Fc-gamma-RIIb; FcRII-b

uniprot entry name :

FCG2B_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Mouse

sequence length :

290

purity :

Serum IgG fraction was purified by Protein A affinity chromatography. Purity: >95%

form :

0.2 um filtered solution in PBS with 5% trehalose.

storage stability :

The lyophilized antibody is stable for at least 1 year from date of receipt at -20 degree C. Upon reconstitution, this antibody can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months without detectable loss of activity. Avoid repeated freeze/thaw cycles. Shelf Life: >12 months

tested application :

ELISA (EIA)

app notes :

ELISA: Use at a concentration range of 0.5-1 ug/ml. The detection limit for FCGR2B is approximately 0.3 ng/well.

other info1 :

Source Note: Polyclonal CD32B antibody was produced from sera of rabbits immunized with recombinant mouse CD32B extracellular domain. Presentation: Lyophilized from 0.2um filtered solution in PBS pH 7.4 with 5% trehalose. Dilution: A quick spin of the vial followed by reconstitution in 0.01M PBS pH 7.4 or other diluents.

other info2 :

Reconstitution: A quick spin of the vial followed by reconstitution in distilled water. This solution can then be diluted into other buffers.

products categories :

Polyclonal

products description :

The inhibitory Fc- receptor IIB (FcRIIB, CD32B), a type I transmembrane receptor with low affinity for monomeric IgG, is a critical regulatory element in B-cell homeostasis. CD32B controls the threshold and the extent of cell activation by counterbalancing the stimulatory activity of a variety of receptors, including the B-cell antigen receptor. Consistent with its regulatory function, CD32B is found on several hematopoietic cell types, which also express activating FcRs, and represents the predominant FcR expressed by the B-cell lineage.

ncbi gi num :

50511932

ncbi acc num :

NP_001002273.1

ncbi gb acc num :

NM_001002273.2

uniprot acc num :

P31994

ncbi mol weight :

34,044 Da

ncbi pathways :

Adaptive Immunity Signaling Pathway (366160); B Cell Receptor Signaling Pathway (198909); B Cell Receptor Signaling Pathway (83081); B Cell Receptor Signaling Pathway (492); BCR Signaling Pathway (138058); Fc Gamma R-mediated Phagocytosis Pathway (114228); Fc Gamma R-mediated Phagocytosis Pathway (106590); Fc-epsilon Receptor I Signaling In Mast Cells Pathway (138050); Immune System Pathway (106386); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (106413)

ncbi summary :

The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

uniprot summary :

FCGR2B iso2: a transmembrane receptor for the Fc region of complexed or aggregated immunoglobulin gamma (IgG). Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down modulation of previous state of cell activation triggered via antigen receptors on B cells, T cells or via another Fc receptor. Three splice-variant isoforms have been observed. Protein type: Cell surface; Oncoprotein; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1q23. Cellular Component: plasma membrane; integral to membrane. Molecular Function: protein binding; IgG binding. Biological Process: regulation of immune response; viral reproduction; immune response; signal transduction. Disease: Systemic Lupus Erythematosus; Malaria, Susceptibility To

size1 :

0.1 mg

price1 :

280 USD

size2 :

0.2 mg

price2 :

385

more info or order :

MyBioSource product webpage