Rabbit anti Human CD32b (FcgRIIB) Polyclonal | MyBioSource MBS551007 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti Human CD32b (FcgRIIB) Polyclonal

catalog :

MBS551007

quantity :

0.1 mg

price :

280 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS551007

products type :

Antibody

products full name :

Rabbit anti Human CD32b (FcgRIIB) Polyclonal

products short name :

CD32b (FcgRIIB)

products name syn :

Rabbit anti Human CD32b (Fcg RII B) Polyclonal purified; Rabbit anti Human CD32b (Fcgamma RII B) Polyclonal purified; Fc RII B; cd32b; cd-32bpolyclonal; PAb

other names :

low affinity immunoglobulin gamma Fc region receptor II-b isoform 2; Low affinity immunoglobulin gamma Fc region receptor II-b; CDw32; Fc-gamma RII-b

products gene name :

CD32

other gene names :

FCGR2B; CD32; FCG2; IGFR2; IgG Fc receptor II-b; Fc-gamma-RIIb; FcRII-b

uniprot entry name :

FCG2B_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

310

purity :

Purification: Serum IgG fraction was purified by Protein A affinity chromatography. Purity: >95%

form :

0.2 um filtered solution in PBS with 5% trehalose.

concentration :

2mg/ml

storage stability :

This antibody can be stored in working aliquots at 2-8 degree C for one month, or at - 20 degree C for 12 months without dectectable loss of activity. Avoid repeated freeze/thaw cycles.

tested application :

ELISA (EIA)

app notes :

ELISA: Use at a concentration range of 0.5-1 ug/ml with the appropriate secondary reagents to detect human CD32b. The detection limit for CD32b is approximately 2.45 pg/well. WB: This polyclonal antibody has been tested in WB analysis of human CD32b. A suitable range of concentrations of this antibody for WB detection is 1-2ug/ml. The detection limit is approx. 0.5ng/well.

other info1 :

Source Note: This antibody was affinity purified from sera of rabbits immunized with recombinant Human CD32b. Presentation: 0.2um Sterile filtered solution in PBS pH 7.4 Containing 5% Trehalose.

other info2 :

Reconstitution: A quick spin of the vial followed by reconstitution in sterile water.

products categories :

Polyclonal

products description :

The inhibitory Fc- receptor IIB (FcRIIB, CD32B), a type I transmembrane receptor with low affinity for monomeric IgG, is a critical regulatory element in B-cell homeostasis. CD32B controls the threshold and the extent of cell activation by counterbalancing the stimulatory activity of a variety of receptors, including the B-cell antigen receptor. Consistent with its regulatory function, CD32B is found on several hematopoietic cell types, which also express activating FcRs, and represents the predominant FcR expressed by the B-cell lineage.

ncbi gi num :

50511932

ncbi acc num :

NP_001002273.1

ncbi gb acc num :

NM_001002273.2

uniprot acc num :

P31994

ncbi mol weight :

34,044 Da

ncbi pathways :

Adaptive Immunity Signaling Pathway (366160); B Cell Receptor Signaling Pathway (198909); B Cell Receptor Signaling Pathway (83081); B Cell Receptor Signaling Pathway (492); BCR Signaling Pathway (138058); Fc Gamma R-mediated Phagocytosis Pathway (114228); Fc Gamma R-mediated Phagocytosis Pathway (106590); Fc-epsilon Receptor I Signaling In Mast Cells Pathway (138050); Immune System Pathway (106386); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (106413)

ncbi summary :

The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

uniprot summary :

FCGR2B iso2: a transmembrane receptor for the Fc region of complexed or aggregated immunoglobulin gamma (IgG). Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down modulation of previous state of cell activation triggered via antigen receptors on B cells, T cells or via another Fc receptor. Three splice-variant isoforms have been observed. Protein type: Membrane protein, integral; Oncoprotein; Cell surface. Chromosomal Location of Human Ortholog: 1q23. Cellular Component: integral to membrane; plasma membrane. Molecular Function: protein binding; IgG binding. Biological Process: regulation of immune response; viral reproduction; immune response; signal transduction. Disease: Systemic Lupus Erythematosus; Malaria, Susceptibility To

size1 :

0.1 mg

price1 :

280 USD

size2 :

0.2 mg

price2 :

385

more info or order :

MyBioSource product webpage