Recombinant Human Fibrobalst Growth Factor-21 (rHuFGF-21) | MyBioSource MBS546114 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Fibrobalst Growth Factor-21 (rHuFGF-21)

catalog :

MBS546114

quantity :

0.005 mg

price :

165 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS546114

products type :

Protein

products full name :

Recombinant Human Fibrobalst Growth Factor-21 (rHuFGF-21)

products short name :

Fibroblast Growth Factor-21

products name syn :

Fibroblast Growth Factor-21; human FGF-21; Human Fibroblast Growth Factor-21

other names :

fibroblast growth factor 21; Fibroblast growth factor 21; fibroblast growth factor 21; FGF-21; fibroblast growth factor 21

other gene names :

FGF21; FGF21; FGF-21

uniprot entry name :

FGF21_HUMAN

host :

E Coli

sequence length :

209

sequence :

MHPIPDSSPL LQFGGQVRQR YLYTDDAQQT EAHLEIREDG TVGGAADQSP ESLLQLKALK PGVIQILGVK TSRFLCQRPD GALYGSLHFD PEACSFRELL LEDGYNVYQS EAHGLPLHLP GNKSPHRDPA PRGPARFLPL PGLPPALPEP PGILAPQPPD VGSSDPLSMV GPSQGRSPSY AS

purity :

>95% by SDS-PAGE and HPLC analyses.

form :

Lyophilized from a 0.2mm filtered concentrated solution in PBS, pH 7.4.

storage stability :

This lyophilized preparation is stable for several weeks at 2-8 degree C, but should be kept at -20 degree C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 degree C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degree C to -70 degree C. Avoid repeated freeze/thaw cycles.

other info1 :

Molecular Weight Information: Approximately 19.1 kDa, a single non-glycosylated polypeptide chain containing 179 amino acids.

other info2 :

Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent stimulation of the proliferation of BaF3 cells expressing FGF receptors is 0.06-0.4ug/ml in the presence of betaKlotho and Heparin. Endotoxin Level: Less than 1EU/mg of rHuFGF-21 as determined by LAL method. Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at <-20 degree C. Further dilutions should be made in appropriate buffered solutions.

products description :

Fibroblast growth factor 21 (FGF21) belongs to the large FGF family which has at least 23 members. All FGF family members are heparin binding growth factors with a core 120 amino acid (aa) FGF domain that allows for a common tertiary structure. FGFs are expressed during embryonic development and in restricted adult tissues. Four distinct but related classes of FGF receptors, FGF R1, 2, 3, and 4, exist. FGF-21, in the presence of betaKlotho as a protein cofactor, signals through the FGFR 1c and 4 receptors and stimulates insulin independent glucose uptake by adipocytes.

ncbi gi num :

9506597

ncbi acc num :

NP_061986.1

ncbi gb acc num :

NM_019113.2

uniprot acc num :

Q9NSA1

ncbi mol weight :

~19.5 kDa, a single non-glycosylated polypeptide chain containing 182 amino acids.

ncbi pathways :

MAPK Signaling Pathway (83048); MAPK Signaling Pathway (456); Melanoma Pathway (83114); Melanoma Pathway (526); PI3K-Akt Signaling Pathway (692234); PI3K-Akt Signaling Pathway (692979); Pathways In Cancer (83105); Proteoglycans In Cancer Pathway (782000); Proteoglycans In Cancer Pathway (782054); Regulation Of Actin Cytoskeleton Pathway (198874)

ncbi summary :

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. [provided by RefSeq, Jul 2008]

uniprot summary :

FGF21: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Belongs to the heparin-binding growth factors family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 19q13.33. Cellular Component: extracellular region. Molecular Function: protein binding; growth factor activity; fibroblast growth factor receptor binding. Biological Process: positive regulation of glucose import; cell-cell signaling; positive regulation of cell proliferation; positive regulation of low-density lipoprotein receptor biosynthetic process; signal transduction

size1 :

0.005 mg

price1 :

165 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2550

more info or order :

MyBioSource product webpage