protein

Recombinant Human Interleukin-2 (rHu IL-2)

MBS546055

0.01 mg

165 USD

Protein

Recombinant Human Interleukin-2 (rHu IL-2)

[Interleukin-2]

[Interleukin-2; human IL-2; Human Interleukin-2]

[interleukin-2; Interleukin-2; interleukin-2; aldesleukin; T cell growth factor; involved in regulation of T-cell clonal expansion; interleukin 2; T-cell growth factor]

[IL2; IL2; IL-2; TCGF; lymphokine; IL-2; TCGF]

IL2_HUMAN

Escherichia Coli

153

MAPSTSSSSTKK TQLQLEHLLL DLQMILGIN NYJNOJKTRM LTFKFYMPPKK ATELKHLQCLEEELKPLEEV LNAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLNRWITFCQSII STLT

>97% by SDS-PAGE and HPLC analyses

Lyophilized from a 0.2mm filtered concentrated (1mg/ml) solution in PBS, pH 7.5. Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder

This lyophilized preparation is stable at 2-8 degree C, but should be kept at -20 degree C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 degree C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degree C to -70 degree C. Avoid repeated freeze/thaw cycles.

Molecular Weight Information: Approximately 15 kDa, a single non-glycosylated polypeptide chain containing 134 amino acids

Interleukin 2 is a protein that has a variety of immunologic functions, the most notable being the ability of IL-2 to promote the proliferation and maturation of activated T cells. A comparison of the amino acid sequences of human and murine IL-2 shows and approximately 60% sequence similarity, and human sequence IL-2 has been found to be active on murine cell lines. Some of the biological activities attributed to IL-2 include. Induction of secretion of interferon-y and tumor necrosis factors a and beta from peripheral blood mononuclear cells. *Stimulation of the rate of synthesis of c-myc RNA and transferrin receptor. *Activation of neutrophils. *Stimulation of proliferation and maturation of activated helper T cells. *Stimulation of proliferation of activated and natural killer cells and tumor infiltrating lymphocytes as well as enhancement of the ability of these cytotoxic lymphocytes to kill target cells. *Induction of the expression of IL-2 receptor on T-cells. *Stimulation of proliferation of antibody- producing B cells.

28178861

NP_000577.2

NM_000586.3

P60568

AhR Pathway (755436); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Calcium Signaling In The CD4+ TCR Pathway (137941); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Cytokine Signaling In Immune System Pathway (366171)

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]

IL2: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family. Protein type: Oncoprotein; Cytokine; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 4q26-q27. Cellular Component: extracellular space; extracellular region. Molecular Function: growth factor activity; interleukin-2 receptor binding; cytokine activity; kinase activator activity; glycosphingolipid binding; carbohydrate binding; kappa-type opioid receptor binding. Biological Process: positive regulation of isotype switching to IgG isotypes; negative regulation of heart contraction; natural killer cell activation; positive regulation of activated T cell proliferation; negative regulation of lymphocyte proliferation; elevation of cytosolic calcium ion concentration; cell-cell signaling; negative regulation of protein amino acid phosphorylation; positive regulation of cell proliferation; protein kinase C activation; positive regulation of B cell proliferation; cell adhesion; T cell differentiation; positive regulation of interleukin-17 production; regulation of T cell homeostatic proliferation; positive regulation of regulatory T cell differentiation; positive regulation of immunoglobulin secretion; positive regulation of cell growth; positive regulation of interferon-gamma production; positive regulation of tissue remodeling; positive regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; immune response; negative regulation of B cell apoptosis; positive regulation of inflammatory response; negative regulation of apoptosis

0.01 mg

165 USD

0.05 mg

205

1 mg

605