protein

P2Y2 Peptide

MBS544096

0.25 mg

250 USD

Blocking Peptide

P2Y2 Peptide

[P2Y2]

[ATP receptor; HP2U; Human P2U nucleotide receptor mRNA complete cds; MGC20088; MGC40010; P2RU1; P2RY2; P2U; P2U nucleotide receptor; P2U purinoceptor 1; P2U receptor 1; P2U1; P2UR; P2Y purinoceptor 2; P2Y2; P2Y2R; Purinergic receptor; Purinergic receptor P2Y G protein coupled 2; Purinergic receptor P2Y2; Purinoceptor P2Y2 antibody]

[purinergic receptor P2Y, G-protein coupled, 2, isoform CRA_a; P2Y purinoceptor 2; P2Y purinoceptor 2; purinergic receptor P2Y2; ATP receptor; P2U purinoceptor 1; P2U1; P2U receptor 1; Purinergic receptor]

[P2Y2]

[P2RY2; P2RY2; P2U; HP2U; P2U1; P2UR; P2Y2; P2RU1; P2Y2R; P2RU1; P2Y2; P2U1]

P2RY2_HUMAN

377

Synthetic Peptide

2.5 mg/ml

Store at -20 degree C for long term storage

Immunodepletion, Immunocompetition

Immunocytochemistry: 1:100. Immunofluorescence: 1:100. Immunohistochemistry: 1:100. Western Blot: 1:500

Immunogen: Synthetic peptide taken within amino acid region 360-410 on rat P2Y2 protein.

Antigenic Blocking Peptide P2Y purinoceptor 2

119595289

EAW74883.1

Q8CHM1

42,273 Da

Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); G Alpha (q) Signalling Events Pathway (1269578); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); GPCRs, Class A Rhodopsin-like Pathway (198886); Gastrin-CREB Signalling Pathway Via PKC And MAPK (1269592); Inflammatory Mediator Regulation Of TRP Channels Pathway (948277); Inflammatory Mediator Regulation Of TRP Channels Pathway (948307); Metabolism Of Proteins Pathway (1268677); Neuroactive Ligand-receptor Interaction Pathway (83053)

The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]

P2Y2: a G-protein coupled receptor of the rhodopsin family. This family includes hormone, neurotransmitter and light receptors. Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP ATP-gamma-S 2-methylthio-ATP = ADP. May participate in control of the cell cycle and proliferation. Protein type: Receptor, misc.; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1. Chromosomal Location of Human Ortholog: 11q13.5-q14.1. Cellular Component: apical plasma membrane; basolateral plasma membrane; cytosol; early endosome; integral to plasma membrane; lysosome; mitochondrion; plasma membrane. Molecular Function: ATP binding; purinergic nucleotide receptor activity, G-protein coupled; receptor activity; UTP-activated nucleotide receptor activity. Biological Process: aging; cellular ion homeostasis; elevation of cytosolic calcium ion concentration; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); in utero embryonic development; negative regulation of ossification; positive regulation of chemokine production; positive regulation of prostaglandin secretion; positive regulation of smooth muscle cell migration; regulation of vasodilation; sensory perception of pain; wound healing

0.25 mg

250 USD