PNPLA3 Antibody | MyBioSource MBS544053 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PNPLA3 Antibody

catalog :

MBS544053

quantity :

0.1 mg Affinity-Puri

price :

390 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, cow

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS544053

products type :

Antibody

products full name :

PNPLA3 Antibody

products short name :

PNPLA3

products name syn :

Acylglycerol O acyltransferase Adiponutrin ADPN C22orf20 Calcium independent phospholipase A2 epsilon IPLA2-epsilon Patatin like phospholipase domain containing 3 phospholipase A2, calcium independent, epsilon

other names :

Patatin-like phospholipase domain-containing protein 3; Patatin-like phospholipase domain-containing protein 3; patatin-like phospholipase domain-containing protein 3; patatin like phospholipase domain containing 3; Acylglycerol O-acyltransferase (EC:2.3.1.-); Adiponutrin; Calcium-independent phospholipase A2-epsilon; iPLA2-epsilon

products gene name :

PNPLA3

other gene names :

PNPLA3; PNPLA3; ADPN; C22orf20; iPLA(2)epsilon; ADPN; C22orf20; iPLA2-epsilon

uniprot entry name :

PLPL3_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Bovine, Human, Mouse, Rat

sequence length :

481

purity :

Immobilized antigen affinity chromatography

form :

Affinity Purified Immunoglobulins

storage stability :

Store at -20 degree C for long term storage.

tested application :

DOT Blot (DB), ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

app notes :

DOT Blot (DB): 1:20,000. ELISA (EIA): 1:20,000. Immunohistochemistry (IHC): 1:50-1:100. Immunoprecipitation (IP): 1:200. Western Blot (WB): 1:500-1:750

other info1 :

Immunoglobulin & Concentration: 0.68 mg/ml IgG in antibody stabilization buffer. Immunogen: Synthetic peptide taken within amino acid region 150-200 on human Patatin-like phospholipase domain-containing protein 3. Expression: By changes in energy balance: down-regulated following very low-calorie diet, whereas refeeding elevates the mRNA level.

other info2 :

Molecular Function: Phospholipase A2 Activity; Lipid degradation and metabolism; Acyltransferase; Hydrolase; Transferase. Structure: Contains 1 patatin domain. Subcellular Location: Membrane; Single-pass type II membrane protein. Related Products: MBS544055: FITC-Conjugated. MBS544298: Antigenic Blocking Peptide

products categories :

Primary Antibodies; Cell Biology; Lipids; PNPLA3 Antibody

products description :

Affinity Purified Patatin-like phospholipase domain-containing protein 3 Antibody

ncbi gi num :

32469599

ncbi acc num :

Q9NST1.2

uniprot acc num :

Q9NST1

ncbi pathways :

Acyl Chain Remodeling Of DAG And TAG Pathway (1270056); Acylglycerol Degradation Pathway (413388); Acylglycerol Degradation Pathway (468272); Adipogenesis Pathway (198832); Eicosanoid Synthesis Pathway (198888); Glycerolipid Metabolism Pathway (82986); Glycerolipid Metabolism Pathway (361); Glycerophospholipid Biosynthesis Pathway (1270054); Metabolic Pathways (132956); Metabolism Pathway (1269956)

ncbi summary :

The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]

uniprot summary :

PNPLA3: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. Genetic variations in PNPLA3 are a cause of susceptibility to non-alcoholic fatty liver disease type 1 (NAFLD1). A condition characterized by an accumulation of excess triglyceride in the liver, a condition known as hepatic steatosis (or fatty liver), which is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Phospholipase; Lipid Metabolism - glycerophospholipid; Secondary Metabolites Metabolism - limonene and pinene degradation; EC 3.1.1.3; Lipid Metabolism - glycerolipid; Amino Acid Metabolism - phenylalanine; Transferase; Amino Acid Metabolism - tyrosine; Membrane protein, integral. Chromosomal Location of Human Ortholog: 22q13.31. Cellular Component: endoplasmic reticulum membrane; integral to membrane; membrane. Molecular Function: acylglycerol O-acyltransferase activity; diolein transacylation activity; lipoprotein lipase activity; mono-olein transacylation activity; phospholipase A2 activity; triacylglycerol lipase activity. Biological Process: triacylglycerol biosynthetic process; triacylglycerol catabolic process

size1 :

0.1 mg Affinity-Purified

price1 :

390 USD

more info or order :

MyBioSource product webpage