protein

Isocitrate dehydrogenase Peptide

MBS543832

0.25 mg

250 USD

Blocking Peptide

Isocitrate dehydrogenase Peptide

[Isocitrate dehydrogenase]

[Cytosolic NADP isocitrate dehydrogenase; Epididymis luminal protein 216; Epididymis secretory protein Li 26; HEL-216; ICDH; IDCD; IDH; Idh1; IDP; IDPC; Isocitrate dehydrogenase [NADP] cytoplasmic; NADP dependent isocitrate dehydrogenase cytosolic; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase; PICD antibody]

[IDH1; Isocitrate dehydrogenase [NADP]; isocitrate dehydrogenase [NADP] cytoplasmic; isocitrate dehydrogenase (NADP(+)) 1, cytosolic]

[IDH1; IDH1; IDH; IDP; IDCD; IDPC; PICD; HEL-216; HEL-S-26]

Q6FI37_HUMAN

414

Antigenic Blocking Peptide

Store at -20°C for long term storage.

Immunodepletion, Immunocompetition

Immunogen: Synthetic peptide. Determinant: N-epitope

Isocitrate dehydrogenase Antigenic Blocking Peptide. Synthetic peptide taken within amino acid region 100-150. Peptide was covalently modified.

49168486

CAG38738.1

Q6FI37

2-Oxocarboxylic Acid Metabolism Pathway (714485); 2-Oxocarboxylic Acid Metabolism Pathway (717400); Abnormal Conversion Of 2-oxoglutarate To 2-hydroxyglutarate Pathway (1269009); Biosynthesis Of Amino Acids Pathway (790012); Biosynthesis Of Amino Acids Pathway (795174); Carbon Metabolism Pathway (814926); Carbon Metabolism Pathway (817567); Central Carbon Metabolism In Cancer Pathway (1059538); Central Carbon Metabolism In Cancer Pathway (1084231); Citrate Cycle (TCA Cycle) Pathway (82927)

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

0.25 mg

250 USD