Phospho-STAT3 Positive Control | MyBioSource MBS543175 product information

product summary

company name :

MyBioSource

product type :

other

product name :

Phospho-STAT3 Positive Control

catalog :

MBS543175

quantity :

5 Applications

price :

310 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS543175

products type :

Positive Control

products full name :

Phospho-STAT3 Positive Control

products short name :

[Phospho-STAT3]

products name syn :

[Acute Phase Response Factor; APRF; DNA binding protein APRF; HIES; Signal Transductor and Activator of Transcription 3 antibody]

other names :

[signal transducer and activator of transcription 3 isoform 1; Signal transducer and activator of transcription 3; signal transducer and activator of transcription 3; signal transducer and activator of transcription 3; Acute-phase response factor]

products gene name :

[STAT3]

other gene names :

[STAT3; STAT3; APRF; HIES; ADMIO]

uniprot entry name :

STAT3_HUMAN

host :

Rabbit

sequence length :

770

form :

Western Blot Positive Control

storage stability :

Store at -20°C for long term storage

tested application :

Western Blot (WB)

app notes :

Western Blot: 1:500

other info1 :

Immunogen: Purified Protein

products description :

Western Blot Positive Control Phosphorylated Signal transducer and activator of transcription

ncbi gi num :

21618340

ncbi acc num :

NP_644805

ncbi gb acc num :

NM_139276.2

uniprot acc num :

P40763

ncbi pathways :

AGE-RAGE Signaling Pathway In Diabetic Complications (1319988); AGE-RAGE Signaling Pathway In Diabetic Complications (1319775); AGE/RAGE Pathway (698754); Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Adipogenesis Pathway (198832); Androgen Receptor Signaling Pathway (198806); Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway (1268699)

ncbi summary :

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]

uniprot summary :

STAT3: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Constitutively active in a number of human tumors. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described. Protein type: Motility/polarity/chemotaxis; Transcription factor; Nuclear receptor co-regulator; DNA-binding. Chromosomal Location of Human Ortholog: 17q21.31. Cellular Component: cytoplasm; cytosol; mitochondrial inner membrane; nuclear chromatin; nucleoplasm; nucleus; plasma membrane. Molecular Function: CCR5 chemokine receptor binding; chromatin DNA binding; DNA binding; glucocorticoid receptor binding; identical protein binding; ligand-dependent nuclear receptor activity; protein binding; protein dimerization activity; protein kinase binding; protein phosphatase binding; signal transducer activity; transcription factor activity; transcription factor binding. Biological Process: acute-phase response; aging; astrocyte differentiation; cell motility; cell proliferation; cellular response to hormone stimulus; cytokine and chemokine mediated signaling pathway; eating behavior; eye photoreceptor cell differentiation; glucose homeostasis; intracellular receptor-mediated signaling pathway; JAK-STAT cascade; leptin-mediated signaling pathway; miRNA-mediated gene silencing, negative regulation of translation; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of glycolysis; negative regulation of transcription from RNA polymerase II promoter; nervous system development; phosphorylation; positive regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of tyrosine phosphorylation of Stat3 protein; protein import into nucleus; radial glial cell differentiation; regulation of cell cycle; regulation of mitochondrial membrane permeability; regulation of multicellular organism growth; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to drug; response to estradiol stimulus; response to ethanol; sexual reproduction; signal transduction; somatic stem cell maintenance; thermoregulation; transcription from RNA polymerase II promoter; viral reproduction. Disease: Autoimmune Disease, Multisystem, Infantile-onset; Hyper-ige Recurrent Infection Syndrome, Autosomal Dominant

size1 :

5 Applications

price1 :

310 USD

more info or order :

MyBioSource product webpage