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Phospho-STAT1 Positive Control

MBS543174

5 Applications

310 USD

Positive Control

Phospho-STAT1 Positive Control

[Phospho-STAT1]

[Signal transducer and activator of transcription 1-alpha/beta; Signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription 1; Transcription factor ISGF-3 components p91/p84]

[STAT1]

[STAT1; STAT1; CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT91]

STAT1_HUMAN

Rabbit

750

Western Blot Positive Control

Store at -20°C for long term storage.

Western Blot (WB).

Western Blot (WB) 1:500

Immunogen: Purified Protein

2507413

P42224.2

P42224

AGE-RAGE Signaling Pathway In Diabetic Complications (1319988); AGE-RAGE Signaling Pathway In Diabetic Complications (1319775); AGE/RAGE Pathway (698754); Adipogenesis Pathway (198832); Antiviral Mechanism By IFN-stimulated Genes Pathway (1269316); B Cell Receptor Signaling Pathway (198909); BDNF Signaling Pathway (712093); CXCR4-mediated Signaling Events Pathway (137910); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864)

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

STAT1: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of certain receptor tyrosine kinases, GPCRs, and receptors for various interleukins and interferons. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 2q32.2. Cellular Component: axon; cytoplasm; cytosol; dendrite; nuclear chromatin; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm. Molecular Function: double-stranded DNA binding; enzyme binding; identical protein binding; protein binding; protein homodimerization activity; signal transducer activity; transcription factor activity; tumor necrosis factor receptor binding. Biological Process: apoptosis; blood circulation; defense response to virus; endothelial cell migration; JAK-STAT cascade; negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of viral protein levels in host cell; positive regulation of mesenchymal cell proliferation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of transcription from RNA polymerase II promoter; response to cAMP; response to cytokine stimulus; response to peptide hormone stimulus; transcription, DNA-dependent; tumor necrosis factor-mediated signaling pathway; viral reproduction. Disease: Immunodeficiency 31a; Immunodeficiency 31b; Immunodeficiency 31c

5 Applications

310 USD