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mTOR Antibody Western Blot Positive Control

MBS542966

5 Applications

290 USD

Positive Control

mTOR Antibody Western Blot Positive Control

[mTOR]

[FK506 binding protein 12 rapamycin associated protein 1; FKBP rapamycin associated protein; FRAP1; FRAP2; mTOR; RAFT1; Rapamycin target protein; RAPT1; Serine/threonine-protein kinase mTOR antibody]

[serine/threonine-protein kinase mTOR; Serine/threonine-protein kinase mTOR; serine/threonine-protein kinase mTOR; mechanistic target of rapamycin; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic target of rapamycin; Rapamycin target protein 1; RAPT1]

[mTOR]

[Mtor; Mtor; Frap1; RAFT1; Frap1; Raft1; mTOR; RAPT1]

MTOR_RAT

Western Blot Positive Control in SDS sample buffer

Store at -20°C for long term storage.

Western Blot (WB)

Western Blot: 1:500

Immunogen: Purified Protein

Western blot positive control Serine/threonine-protein kinase mTOR Antibody

9845251

NP_063971.1

NM_019906.1

P42346

AMPK Signaling Pathway (989832); AMPK Signaling Pathway (992181); Acute Myeloid Leukemia Pathway (83505); Acute Myeloid Leukemia Pathway (529); Adaptive Immune System Pathway (1377120); Adipocytokine Signaling Pathway (83485); Adipocytokine Signaling Pathway (505); Alpha6-Beta4 Integrin Signaling Pathway (198503); CD28 Co-stimulation Pathway (1377127); CD28 Dependent PI3K/Akt Signaling Pathway (1377128)

binds the complex formed by the immunosuppressive drug rapamycin and its receptor FKBP12; may play a role in the cell cycle G1 to S transition [RGD, Feb 2006]

mTOR: an atypical kinase belonging to the PIKK family of kinases. Is the catalytic subunit of two protein complexes, mTORC1 and mTORC2. mTORC1 activates S6K and inactivates 4E-BP1, up-regulating protein synthesis. mTORC1 contains Raptor, a positive regulatory subunit and scaffold for recruiting substrates, two negative regulators, PRAS40 and DEPTOR, and mLST8; it is a target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. mTORC2, a downstream effector of PI3K, is insensitive to rapamycin and activates Akt by phosphorylating a key activation site. mTORC2 contains regulatory subunits Rictor and mSIN1, PROTOR, mLST8, and the negative regulator DEPTOR. mTORC1 suppresses PI3K activity via a strong negative feedback loop that involves S6K1. Inhibiting mTORC1 ablates this negative feedback loop and potentiates PI3K signaling. Known inhibitors of mTOR include rapamycin, temsirolimus (CCI-779). Protein type: Motility/polarity/chemotaxis; Autophagy; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Kinase, protein; EC 2.7.11.1; ATYPICAL group; PIKK family; FRAP subfamily. Cellular Component: cell soma; cytoplasm; cytosol; dendrite; endomembrane system; endoplasmic reticulum membrane; Golgi membrane; lysosomal membrane; lysosome; membrane; mitochondrial outer membrane; nucleus; PML body; TORC2 complex. Molecular Function: ATP binding; drug binding; kinase activity; phosphoprotein binding; phosphotransferase activity, alcohol group as acceptor; protein binding; protein domain specific binding; protein kinase binding; protein serine/threonine kinase activity; ribosome binding. Biological Process: 'de novo' pyrimidine base biosynthetic process; brain development; cardiac cell development; cardiac muscle cell development; cardiac muscle contraction; cardiac muscle development; cell aging; cell growth; cell projection organization and biogenesis; cellular response to nutrient levels; DNA repair; energy reserve metabolic process; germ cell development; heart morphogenesis; long-term memory; maternal process involved in pregnancy; mRNA stabilization; multicellular organism growth; negative regulation of autophagy; negative regulation of cell size; negative regulation of macroautophagy; negative regulation of muscle atrophy; negative regulation of NFAT protein import into nucleus; negative regulation of protein amino acid phosphorylation; negative regulation of protein ubiquitination; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of actin filament polymerization; positive regulation of endothelial cell proliferation; positive regulation of lipid biosynthetic process; positive regulation of neurogenesis; positive regulation of neuron maturation; positive regulation of nitric oxide biosynthetic process; positive regulation of oligodendrocyte differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of smooth muscle cell proliferation; positive regulation of stress fiber formation; positive regulation of transcription from RNA polymerase III promoter; positive regulation of translation; post-embryonic development; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of actin cytoskeleton organization and biogenesis; regulation of carbohydrate metabolic process; regulation of carbohydrate utilization; regulation of fatty acid beta-oxidation; regulation of glycogen biosynthetic process; regulation of GTPase activity; regulation of myelination; regulation of osteoclast differentiation; regulation of protein kinase activity; regulation of protein kinase B signaling cascade; regulation of response to food; response to amino acid stimulus; response to cocaine; response to insulin stimulus; response to morphine; ruffle organization and biogenesis; social behavior; spinal cord development; TOR signaling pathway; visual learning; voluntary musculoskeletal movement; wound healing

5 Applications

290 USD