product summary
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company name :
MyBioSource
product type :
other
product name :
FAM38A Positive Control
catalog :
MBS542755
quantity :
5 Applications
price :
290 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS542755
products type :
Positive Control
products full name :
FAM38A Positive Control
products short name :
[FAM38A]
products name syn :
[DHS; Fam38a; Family with sequence similarity 38 member A; KIAA0233; Membrane protein induced by beta-amyloid treatment; Mib; Piezo-type mechanosensitive ion channel component 1; Protein FAM38A; Protein FAM38B; Protein PIEZO1 antibody]
other names :
[Piezo-type mechanosensitive ion channel component 1; Piezo-type mechanosensitive ion channel component 1; piezo-type mechanosensitive ion channel component 1; piezo type mechanosensitive ion channel component 1; Membrane protein induced by beta-amyloid treatment; Mib; Protein FAM38A]
products gene name :
[FAM38A]
other gene names :
[PIEZO1; PIEZO1; DHS; Mib; LMPH3; FAM38A; FAM38A; KIAA0233; Mib]
uniprot entry name :
PIEZ1_HUMAN
sequence length :
2521
storage stability :
-20 degree C for long term storage
tested application :
Western Blot Positive Control
app notes :
Western Blot: 1:500
other info1 :
Expression: Expressed in numerous tissues. In normal brain, expressed exclusively in neurons, not in astrocytes; Expressed in erythrocytes. Volume: 20ul/lane (SDS-PAGE) of the FAM38A positive control is recommended.
other info2 :
Molecular Function: Ion channel. Structure: Homooligomer, most likely homotetramer. Subcellular Location: Cell membrane, Endoplasmic Reticulum, Membrane
products description :
Western Blot Positive control for the FAM38A antibody MBS540520.
ncbi gi num :
317373533
uniprot acc num :
Q92508
ncbi mol weight :
286,790 Da
ncbi summary :
The protein encoded by this gene is a mechanically-activated ion channel that links mechanical forces to biological signals. The encoded protein contains 36 transmembrane domains and functions as a homotetramer. Defects in this gene have been associated with dehydrated hereditary stomatocytosis. [provided by RefSeq, Jul 2015]
uniprot summary :
PIEZO1: Component of mechanosensitive channel required for the mechanosensitive currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. Belongs to the PIEZO family. Protein type: Endoplasmic reticulum; Membrane protein, multi-pass; Membrane protein, integral. Chromosomal Location of Human Ortholog: 16q24.3. Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; integral to membrane; plasma membrane. Molecular Function: cation channel activity; mechanically-gated ion channel activity. Biological Process: cation transport; positive regulation of cell-cell adhesion mediated by integrin; positive regulation of integrin activation. Disease: Dehydrated Hereditary Stomatocytosis With Or Without Pseudohyperkalemia And/or Perinatal Edema
size1 :
5 Applications
price1 :
290 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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