protein

CD2 Peptide

MBS542679

0.25 mg

250 USD

Blocking Peptide

CD2 Peptide

[CD2]

[CD 2; CD2 antigen (p50), sheep red blood cell receptor; Erythrocyte receptor; FLJ46032; LFA-2; LFA-3 receptor; Ly-37; Lymphocyte function antigen 2; p50; Rosette receptor; Sheep erythrocyte receptor; T cell surface antigen CD2; T cell surface antigen T11/Leu 5 antibody]

[T-cell surface antigen CD2; T-cell surface antigen CD2; T-cell surface antigen CD2; CD2 molecule; Erythrocyte receptor; LFA-2; LFA-3 receptor; Rosette receptor; T-cell surface antigen T11/Leu-5; CD_antigen: CD2]

[CD2]

[CD2; CD2; T11; SRBC; LFA-2; SRBC]

CD2_HUMAN

[335-351]

351

Synthetic Peptide

Quantity: 250 ug; Volume: 100 ul

-20 degree C for long term storage

Immunodepletion, Competition Assay

Immunohistochemistry: 1:100. Western Blot: 1:500

Immunogen: Synthetic peptide corresponding to amino acid region 3335-351 on human T-cell surface antigen CD2 protein.

Determinant: C-epitope. Molecular Function: Cell adhesion. Structure: Cytoplasmic domain is implicated in signaling function. Contains 1 Ig-like C2-type domain and 1 Ig-like V-type domain. Subcellular Location: Membrane; Single-pass type I membrane protein.

Antigenic Blocking Peptide T-cell surface antigen CD2 Extreme C-epitope. Interacts with lymphocyte function associated antigen and CD48/BCM1 to mediate adhesion between T-cells and other cells.

156071472

NP_001758

NM_001767.3

P06729

39,448 Da

Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Surface Interactions At The Vascular Wall Pathway (1269373); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Hemostasis Pathway (1269340)

CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]

CD2: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function. Protein type: Cell surface; Apoptosis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1p13.1. Cellular Component: anchored to plasma membrane; cell surface; external side of plasma membrane; extracellular region; integral to plasma membrane; intercellular junction; internal side of plasma membrane; plasma membrane. Molecular Function: protein binding; protein homodimerization activity; receptor activity; receptor binding. Biological Process: apoptosis; cell surface receptor linked signal transduction; cell-cell adhesion; heterotypic cell-cell adhesion; leukocyte migration; lipid raft polarization; natural killer cell activation; positive regulation of myeloid dendritic cell activation; positive regulation of tumor necrosis factor production; regulation of T cell differentiation; T cell activation

0.25 mg

250 USD