antibody

Norepinephrine Transporter Antibody FITC

MBS542214

0.1 mg

495 USD

polyclonal

rabbit

FITC

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, enzyme immunoassay

Antibody

Norepinephrine Transporter Antibody FITC

[Norepinephrine Transporter]

[NAT1; NET; NET1; Neurotransmitter transporter; Norepinephrine transporter; SLC6A2; SLC6A5; Sodium dependent noradrenaline transporter; Solute carrier family 6 (neurotransmitter transporter norepinephrine) member 5; Solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2; Solute carrier family 6 member 2; Solute carrier family 6 member 5 antibody]

[Sodium-dependent noradrenaline transporter; Sodium-dependent noradrenaline transporter; sodium-dependent noradrenaline transporter; solute carrier family 6 member 2; Norepinephrine transporter; NET; Solute carrier family 6 member 2]

[SLC6A2; SLC6A2; NET; NAT1; NET1; SLC6A5; NAT1; NET1; SLC6A5; NET]

SC6A2_HUMAN

Polyclonal

Rabbit

Human, Mouse, Rat

FITC-conjugated Immunoglobulins

0.68mg/ml IgG in antibody stabilization buffer

Store at -20°C for long term storage.

ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

ELISA: 1:4,000. Immunocytochemistry: 1:100. Immunofluorescence: 1:100. Immunohistochemistry: 1:100. Immunoprecipitation: 1:200. Western Blot: 1:250

Immunogen: Synthetic peptide corresponding to N-terminal amino acids that are unique to noradrenaline transporter protein. The antibodies are raised utilizing linear, multiple antigenic peptides or cyclic peptide methodology.

128616

P23975.1

P23975

Monoamine Transport Pathway (198851); Na+/Cl- Dependent Neurotransmitter Transporters Pathway (1269934); SLC-mediated Transmembrane Transport Pathway (1269907); Transmembrane Transport Of Small Molecules Pathway (1269903); Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway (1269923)

This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

SLC6A2: Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals. Defects in SLC6A2 are a cause of orthostatic intolerance (OI). OI is a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily. Protein type: Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 16q12.2. Cellular Component: integral to plasma membrane; membrane; neuron projection; plasma membrane. Molecular Function: dopamine:sodium symporter activity; metal ion binding; monoamine transmembrane transporter activity; norephinephrine:sodium symporter activity; protein binding. Biological Process: dopamine uptake; monoamine transport; norepinephrine transport; response to pain; synaptic transmission; transmembrane transport; transport. Disease: Orthostatic Intolerance

0.1 mg

495 USD