product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rabbit Polyclonal Anti-MOTS-c antibody
catalog :
MBS542112
quantity :
0.1 mg
price :
425 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
application :
western blot, ELISA, immunoprecipitation
more info or order :
image
image 1 :
WB of MBS542112 with HepG2 cells. Image courtesy of anonymous user.
image 2 :
Rat Skeletal Muscle- MOTS-c . Primary Antibody: MBS542112; 1:50 dilution in IHC Blocking Buffer. DAB (brown) staining and Hematoxylin QS (blue) counterstain. 40X magnification on Leica DM4000. FFPE section.
product information
catalog number :
MBS542112
products type :
Antibody
products full name :
Rabbit Polyclonal Anti-MOTS-c antibody
products short name :
[MOTS-c]
products name syn :
[Mitochondrial Derived Peptide MOTS-c; MOTS; MOTS c]
other names :
[MOTS-c; Mitochondrial-derived peptide MOTS-c; Mitochondrial open reading frame of the 12S rRNA-c]
products gene name :
[MOTS-c]
other gene names :
[MT-RNR1]
uniprot entry name :
MOTSC_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Human, Rat
sequence length :
16
form :
Affinity Purified Immunoglobulins
concentration :
0.75 mg/ml IgG in antibody stabilization buffer
storage stability :
Store at -20°C for long term storage.
tested application :
ELISA, Immunoprecipitation (IP), Western Blot (WB)
app notes :
Dot Blot: 1:10,000. ELISA: 1:10,000. Immunoprecipitation: 1:200. Western Blot: 1:500. Dilutions are for preference only. Applications are not necessarily precluded from working with this antibody.
image1 heading :
Western Blot (WB)
image2 heading :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Full-length peptide corresponding to amino acids 1-16 on MOTS-c.
products categories :
Primary Antibodies; Cell Biology; Organelles; Mitochondria; MOTS-c Antibody
products description :
Mitochondria are functioning organelles that play a secondary role in signaling within the cell. While the details of mitochondrial signaling are not fully understood, the identification of an open reading frame in the mitochondrial DNA coding for humanin suggests that there are more signaling peptides coded by portions of the mtDNA. A short open reading frame within the 12S subunit of the mitochondrial ribosomal RNA codes for a 16 amino acid peptide called mitochondrial open reading frame of 12S rRNA-c, or MOTS-c. MOTS-c plays a role in insulin sensitivity and metabolic homeostasis (1). MOTS-c targets skeletal muscle tissue, and the mechanism of its action involves inhibition of the folate cycle. MOTS-c promotes the formation of an endogenous AMP analog called 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR). AICAR is an activator of AMPK, suggesting that MOTS-c could be used in an insulin-regulation capacity in order to treat type 2 diabetes (2). MOTS-c selective antibodies were generated against a peptide taken from the human protein. The MOTS-c-selective antibodies are affinity purified on an immobilized antigen based affinity matrix, the isolated antibodies were then stabilized in antibody stabilization buffer for long-term storage. The MOTS-c-selective antibodies are fully characterized for applications in western blotting and ELISA at the recommended dilutions.
ncbi gi num :
756542780
ncbi acc num :
AJM13597.1
uniprot summary :
MT-RNR1: Regulates insulin sensitivity and metabolic homeostasis. Inhibits the folate cycle, thereby reducing de novo purine biosynthesis which leads to the accumulation of the de novo purine synthesis intermediate 5-aminoimidazole-4-carboxamide (AICAR) and the activation of the metabolic regulator 5'-AMP-activated protein kinase (AMPK). Protects against age-dependent and diet-induced insulin resistance as well as diet-induced obesity. {ECO:0000269 PubMed:25738459}. Disease: Deafness, Nonsyndromic Sensorineural, Mitochondrial
size1 :
0.1 mg
price1 :
425 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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