antibody

IP3 receptor Antibody Affinity Purified

MBS541925

0.1 mg

390 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat, cow

western blot, ELISA, enzyme immunoassay

Antibody

IP3 receptor Antibody Affinity Purified

[IP3 receptor]

[5-trisphosphate receptor; DKFZp313N1434; inositol 1 4 5 triphosphate receptor type 1; Inositol 1; InsP3R1; IP3; IP3 receptor; IP3R1; ITPR 1; SCA15; SCA16; SCA29; Type 1 inositol 1 4 5 trisphosphate receptor; Type 1 inositol 1 antibody]

[inositol 1,4,5-trisphosphate receptor type 1 isoform 1; Inositol 1,4,5-trisphosphate receptor type 1; inositol 1,4,5-trisphosphate receptor type 1; inositol 1,4,5-trisphosphate receptor type 1; IP3 receptor isoform 1; IP3R 1; InsP3R1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor]

[IP3]

[ITPR1; ITPR1; ACV; CLA4; IP3R; IP3R1; SCA15; SCA16; SCA29; INSP3R1; PPP1R94; INSP3R1; IP3R 1; InsP3R1; Type 1 InsP3 receptor]

ITPR1_HUMAN

Polyclonal

Rabbit

Bovine, Human, Monkey, Mouse, Rat

2710

Affinity Purified Immunoglobulins

0.75 mg/ml IgG in antibody stabilization buffer

-20 degree C for long term storage

ELISA (EIA), Western Blot (WB)

Dot Blot: 1:10,000. ELISA: 1:10,000. Western Blot: 1:500

Western Blot (WB)

Immunogen: Synthetic peptide corresponding to unique amino acid sequence on human ITPR subtype 1 protein. Expression: Widely expressed

Molecular Function: Calcium channel, Ion channel, Ligand-gated ion channel, Receptor. Structure: Homotetramer. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channe. Subcellular Location: Endoplasmic Reticulum membrane; Multi-pass membrane protein

Primary Antibodies; Signal Transduction; Calcium Binding; IP3 receptor Antibody

Affinity Purified Inositol 1, 4, 5-trisphosphate receptor type isoform 1 Antibody. Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1, 4, 5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).

269954690

NP_001093422.2

NM_001099952.2

Q14643

309,338 Da

Adaptive Immune System Pathway (1269171); Aldosterone Synthesis And Secretion Pathway (1272485); Aldosterone Synthesis And Secretion Pathway (1285075); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway (1269184); Apoptosis Pathway (83060); Apoptosis Pathway (470); B Cell Receptor Signaling Pathway (198909)

This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]

IP3R1: a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaMKII, eventually leading to the activation of downstream apoptosis pathways. Part of a cGMP kinase signaling complex that includes alpha-actin, calponin H1, phospholamban, PKG1 and IP3R1. Widely expressed. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylation by PKA prevents the ligand-induced opening of the calcium channels. Belongs to the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family. Eight alternatively spliced isoforms have been described. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium; Channel, ligand-gated. Chromosomal Location of Human Ortholog: 3p26.1. Cellular Component: calcineurin complex; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; membrane; nuclear inner membrane; nucleolus; platelet dense granule membrane; postsynaptic density; sarcoplasmic reticulum. Molecular Function: calcium channel inhibitor activity; calcium ion transmembrane transporter activity; calcium-release channel activity; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity; phosphoinositide binding; protein binding. Biological Process: calcium ion transport; endoplasmic reticulum calcium ion homeostasis; epithelial fluid transport; inositol phosphate-mediated signaling; negative regulation of calcium-mediated signaling; platelet activation; post-embryonic development; regulation of autophagy; regulation of insulin secretion; release of sequestered calcium ion into cytosol; response to hypoxia; signal transduction; voluntary musculoskeletal movement

0.1 mg

390 USD