catalog number :
MBS541832
products full name :
Rabbit Polyclonal Anti-Humanin Antibody
products short name :
[Humanin]
products name syn :
[HN; HUNIN; MT-RNR2 antibody]
other names :
[humanin-like 2; Humanin-like 2; humanin-like 2; MT-RNR2-like 2; MT-RNR2-like protein 2]
other gene names :
[MTRNR2L2; MTRNR2L2; HN2; HN2]
uniprot entry name :
HMN2_HUMAN
reactivity :
Human, Monkey
sequence :
GFSCLLLSTTATDLPVKRRT
specificity :
Will detect all isoforms except Humanin 9.
form :
Affinity Purified Immunoglobulins
concentration :
0.62 mg/ml IgG in antibody stabilization buffer
storage stability :
-20 degree C for long term storage
tested application :
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB), Dot Blot (DB)
app notes :
Recommended Dilution:. ELISA: 1:10,000. Immunoprecipitation: 1:200. Western Blot: 1:500. Dot Blot: 1:10,000
other info1 :
Immunogen: Synthetic peptide corresponding to amino acid region 5-24 on Humanin protein
products categories :
Primary Antibodies; Neuroscience; Neurodegenerative Disease; Alzheimer s Research; Amyloid; Humanin Antibody
products description :
Humanin is a peptide that is 21 or 24 amino acids long whether it is produced in the mitochondria or cytosol respectively (1). Humanin is encoded by the mi16S ribosomal RNA gene MT-RNR2 (2). Humanin is believed to have neuroprotective and cytoprotective effects. Studies have found human in and humanin derivatives increase survival and physiological parameters in Alzheimer's disease models (3). Humanin is also believed to play neuroprotective roles in Huntington's deisease, pnon disease and strokes (4). Humanin may playa role in various other ailments including protection against oxidative stress, atherosclerotic plaque formation, heart attack and diabetes. (5, 6, 7, 8, 9). The pan-Humanin selective antibodies were generated using a synthetic peptide corresponding to amino acid region 5-24 on human Humanin peptide. The Humanin antibodies are affinity purified over immobilized antigen based affinity chromatography. The purified immunoglobulins are prepared in stabilization buffer for long term storage Antigenic blocking peptides (P-HUMN), and western blot positive control (pC-HUMN) in ready to use SDS-sample buffer are available Antibodies can be conjugated to fluorophores and other secondary enzymes upon request at nominal cost The pan-Humanin selective antibodies will label all Humanin isoforms except Humanin 9. Humanin 9-selective antibody (Please Inquire) is available for detection of only the Humanin 9 isoform.
ncbi acc num :
NP_001177399.1
ncbi gb acc num :
NM_001190470.1
uniprot summary :
MTRNR2L2: Plays a role as a neuroprotective and antiapoptotic factor. Belongs to the humanin family. Chromosomal Location of Human Ortholog: 5q14.1. Cellular Component: cytoplasm; extracellular region