antibody

GPCR GPR43 Antibody

MBS541594

0.1 mg

390 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunoprecipitation, enzyme immunoassay, dot blot

Antibody

GPCR GPR43 Antibody

[GPCR GPR43 / FFAR2]

[FFA2R; free fatty acid activated receptor 2; Free fatty acid receptor 2; G-protein coupled receptor 43; GPR 43 antibody]

[free fatty acid receptor 2; Free fatty acid receptor 2; free fatty acid receptor 2; free fatty acid receptor 2; G-protein coupled receptor 43]

[GPCR GPR43]

[FFAR2; FFAR2; FFA2R; GPR43; FFA2; GPCR43; GPR43]

FFAR2_HUMAN

Polyclonal

Rabbit

Human, Mouse, Rat

330

Affinity Purified

0.75 mg/ml IgG in antibody stabilization buffer

-20 degree C for long term storage

Dot Blot (DB), ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

Dot Blot: 1:10,000. ELISA: 1:10,000. Immunoprecipitation: 1:150. Western Blot: 1:500. Immunohistochemistry: 1:150

Western Blot (WB)

Immunogen: Synthetic peptide taken within amino acid region 250-300 on human free fatty acid receptor 2 protein.

Primary Antibodies; Signal Transduction; G-Protein Coupled Receptors; GPCR GPR43 / FFAR2 Antibody

Affinity Purified Free fatty acid receptor 2 Antibody Mid Region. G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family.

4885333

NP_005297.1

NM_005306.2

O15552

Class A/1 (Rhodopsin-like Receptors) Pathway (1269545); Free Fatty Acid Receptors Pathway (1269569); G Alpha (q) Signalling Events Pathway (1269578); GPCR Downstream Signaling Pathway (1269574); GPCR Ligand Binding Pathway (1269544); GPCRs, Class A Rhodopsin-like Pathway (198886); Gastrin-CREB Signalling Pathway Via PKC And MAPK (1269592); Signal Transduction Pathway (1269379); Signaling By GPCR Pathway (1269543); CAMP Signaling Pathway (1017634)

This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels. [provided by RefSeq, Apr 2009]

FFAR2: Receptor for short chain fatty acids through a G(i)- protein-mediated inhibition of adenylyl cyclase and elevation of intracellular calcium. The rank order of potency for agonists of this receptor is acetate= propionate = butyrate pentanoate = formate. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 19q13.1. Cellular Component: cell projection; integral to plasma membrane; plasma membrane. Molecular Function: G-protein coupled receptor activity; lipid binding; protein binding. Biological Process: cell surface pattern recognition receptor signaling pathway; fat cell differentiation; G-protein coupled receptor protein signaling pathway; glucose homeostasis; leukocyte chemotaxis during inflammatory response; mucosal immune response; positive regulation of acute inflammatory response to non-antigenic stimulus; positive regulation of chemokine production; positive regulation of cytokine production during immune response; regulation of acute inflammatory response; sequestering of lipid

0.1 mg

390 USD