product summary
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company name :
MyBioSource
product type :
antibody
product name :
TM6SF2 Antibody
catalog :
MBS540831
quantity :
0.1 mg
price :
390 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunoprecipitation, enzyme immunoassay
more info or order :
image
image 1 :
image 2 :
product information
catalog number :
MBS540831
products type :
Antibody
products full name :
TM6SF2 Antibody
products short name :
[TM6SF2]
products name syn :
[TM6S2_HUMAN; tm6sf2; Transmembrane 6 superfamily member 2 antibody]
other names :
[transmembrane 6 superfamily member 2; Transmembrane 6 superfamily member 2; transmembrane 6 superfamily member 2; transmembrane 6 superfamily member 2]
products gene name :
[TM6SF2]
other gene names :
[TM6SF2; TM6SF2]
uniprot entry name :
TM6S2_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
377
form :
Affinity Purified
concentration :
0.68 mg/ml IgG in antibody stabilization buffer
storage stability :
-20 degree C for long term storage
tested application :
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
app notes :
ELISA: 1:4,000. Immunoprecipitation: 1:150. Western Blot: 1:500. Note: Dilutions are for reference only. Applications not listed above are not necessarily precluded from working with this antibody. investigators intending to use an application that has not beer. verified can request a complimentary sample.
image1 heading :
Western Blot (WB)
image2 heading :
Western Blot (WB)
image3 heading :
Western Blot (WB)
other info1 :
Immunogen: Synthetic peptide taken within amino acid region 220-270 on mouse TM6SF2 protein.
other info2 :
Molecular Function: Integral component of membrane. Structure: Transmembrane helix; Belongs to TM6SF family
products categories :
Primary Antibodies; Cell Biology; TM6SF2 Antibody
products description :
Transmembrane 6 superfamily member 2 (TM6SF2) is a 377 amino acid multi-pass membrane protein that belongs to the TM6SF family which is intricately involved in chemokine signal transduction pathways. TM6SF2, a gene expressed predominantly in liver and intestine comprises of 7-10 predicted transmembrane domains. TM6SF2 siRNA inhibition is associated with reduced secretion of TRLs and increased cellular TG concentration and lipid droplet content, whereas TM6SF2 overexpression reduced liver cell steatosis concluding that TM6SF2 is a regulator of liver fat metabolism with opposing effects on the secretion of TRLs and hepatic lipid droplet content (1). Protein subcellular localization stud ies with confocal microscopy demonstrated that TM6SF2 is localized in the endoplasmic reticulum and the ERGolgi intermediate compartment of human liver cells (2).
ncbi gi num :
112181177
ncbi acc num :
NP_001001524
ncbi gb acc num :
NM_001001524.2
uniprot acc num :
Q8R1J1
ncbi mol weight :
39,417 Da
uniprot summary :
TM6SF2: Belongs to the TM6SF family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 19p13.3-p12. Cellular Component: endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; integral to membrane. Biological Process: lipid metabolic process; regulation of lipid metabolic process
size1 :
0.1 mg
price1 :
390 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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