IL23 P19 Antibody | MyBioSource MBS540708 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

IL23 P19 Antibody

catalog :

MBS540708

quantity :

0.1 mg

price :

390 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS540708

products type :

Antibody

products full name :

IL23 P19 Antibody

products short name :

[IL23 P19]

products name syn :

[alpha subunit P19; IL-23 subunit alpha; IL-23-A; IL-23p19; IL23; interleukin 23 alpha subunit p19; JKA3 induced upon T cell activation; MGC79388; P19; SGRF antibody]

other names :

[interleukin-23 subunit alpha; Interleukin-23 subunit alpha; interleukin-23 subunit alpha; interleukin 23 subunit alpha; Interleukin-23 subunit p19; IL-23p19]

products gene name :

[IL23 P19]

other gene names :

[IL23A; IL23A; P19; SGRF; IL-23; IL-23A; IL23P19; SGRF; IL-23 subunit alpha; IL-23-A; IL-23p19]

uniprot entry name :

IL23A_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

189

specificity :

This antibody does not cross react with other Interleukins or other proteins.

form :

Affinity Purified

concentration :

0.75 mg/ml IgG in antibody stablization buffer

storage stability :

Store at -20°C for long term storage.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

Dot Blot: 1:10,000. ELISA: 1:10,000. Western Blot: 1:250

other info1 :

Immunogen: Synthetic peptide corresponding to C terminal region amino acids 162-179 of Human IL23 P19. Peptide was covalently modified.

products categories :

Primary Antibodies; Immunology; Innate Immunity; Macrophage / Inflammation; IL23 P19 Antibody

ncbi gi num :

7706702

ncbi acc num :

NP_057668.1

ncbi gb acc num :

NM_016584.2

uniprot acc num :

Q9NPF7

ncbi pathways :

ATF-2 Transcription Factor Network Pathway (138006); Cytokine Signaling In Immune System Pathway (1269310); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); IL23-mediated Signaling Events Pathway (138000); Immune System Pathway (1269170); Inflammatory Bowel Disease (IBD) Pathway (842771); Inflammatory Bowel Disease (IBD) Pathway (842797); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488)

ncbi summary :

This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]

uniprot summary :

IL23A: Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Belongs to the IL-6 superfamily. Protein type: Cytokine; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 12q13.3. Cellular Component: extracellular region. Molecular Function: cytokine activity; interleukin-23 receptor binding; protein binding. Biological Process: defense response to Gram-negative bacterium; defense response to virus; inflammatory response; innate immune response; negative regulation of interleukin-10 production; positive regulation of activated T cell proliferation; positive regulation of defense response to virus by host; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of inflammatory response; positive regulation of interferon-gamma production; positive regulation of interleukin-10 production; positive regulation of interleukin-12 production; positive regulation of interleukin-17 production; positive regulation of memory T cell differentiation; positive regulation of natural killer cell activation; positive regulation of natural killer cell proliferation; positive regulation of NF-kappaB import into nucleus; positive regulation of NK T cell activation; positive regulation of NK T cell proliferation; positive regulation of osteoclast differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of T cell proliferation; positive regulation of T-helper 1 type immune response; positive regulation of tissue remodeling; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of tyrosine phosphorylation of Stat4 protein; positive regulation of tyrosine phosphorylation of Stat5 protein; regulation of tyrosine phosphorylation of Stat1 protein; T cell proliferation; tissue remodeling

size1 :

0.1 mg

price1 :

390 USD

more info or order :

MyBioSource product webpage