CD10 Antibody | MyBioSource MBS540557 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CD10 Antibody

catalog :

MBS540557

quantity :

0.1 mg Affinity-Puri

price :

390 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS540557

products type :

Antibody

products full name :

CD10 Antibody

products short name :

CD10

products name syn :

Atriopeptidase; CALLA; CD10; Common acute lymphocytic leukemia antigen; DKFZp686O16152; EC 3.4.24.11; Enkephalinase; EPN; gp100; Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10); Membrane metallo endopeptidase; MGC126681; MGC126707; MME; NEP; Neprilysin; Neutral endopeptidase; SFE; Skin fibroblast elastase antibody

other names :

neprilysin; Neprilysin; neprilysin; membrane metallo-endopeptidase; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD_antigen: CD10

products gene name :

CD10

other gene names :

MME; MME; NEP; SFE; CD10; CALLA; EPN; CALLA; NEP; Neutral endopeptidase; SFE

uniprot entry name :

NEP_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

750

form :

Affinity Purified

concentration :

0.72-0.78 ug/ul in antibody stabilization buffer

storage stability :

-20 degree C for long term storage

tested application :

Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

app notes :

ELISA: 1:10,000. Immunocytochemistry: 1:250. Immunofluorescence: 1:250. Immunohistochemistry: 1:250. Immunoprecipitation: 1:250. Western Blot: 1:500

other info1 :

Immunogen: Synthetic peptide taken within amino acid region 100-150 on human Neprilysin protein. Immunoglobulin: IgG. Expression: Adipose tissue; duodenum; kidney; small intestine

other info2 :

Determinant: Extreme N-epitope. Molecular Function: Hydrolase, Metalloprotease, Protease. Structure: Belongs to the peptidase M13 family. Subcellular Location: Cell membrane, Membrane

products categories :

Primary Antibodies; Cancer Research; CD Markers; CD10 Antibody

products description :

Affinity Purified Neprilysin Antibody Extreme N-epitope. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. angiotensin maturation; cellular response to UV; replicative senescence

ncbi gi num :

116256327

ncbi acc num :

NP_009218

ncbi gb acc num :

NM_007287.2

uniprot acc num :

P08473

ncbi mol weight :

85,514 Da

ncbi pathways :

Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Alzheimers Disease Pathway (672448); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Metabolism Of Angiotensinogen To Angiotensins Pathway (1268749); Metabolism Of Proteins Pathway (1268677); Peptide Hormone Metabolism Pathway (1268746); Protein Digestion And Absorption Pathway (172847); Protein Digestion And Absorption Pathway (171868)

ncbi summary :

This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]

uniprot summary :

CD10: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers. Inhibited in a dose dependent manner by opiorphin. Belongs to the peptidase M13 family. Protein type: EC 3.4.24.11; Protease; Membrane protein, integral. Chromosomal Location of Human Ortholog: 3q25.2. Cellular Component: axon; brush border; cytoplasm; dendrite; focal adhesion; integral to membrane; integral to plasma membrane; plasma membrane; synapse; synaptic vesicle. Molecular Function: endopeptidase activity; exopeptidase activity; metalloendopeptidase activity; metallopeptidase activity; peptide binding; protein binding; zinc ion binding. Biological Process: angiotensin maturation; beta-amyloid metabolic process; creatinine metabolic process; kidney development; peptide metabolic process; proteolysis; sensory perception of pain. Disease: Membranous Nephropathy, Susceptibility To

size1 :

0.1 mg Affinity-Purified

price1 :

390 USD

more info or order :

MyBioSource product webpage