TLR5 Antibody | MyBioSource MBS540533 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

TLR5 Antibody

catalog :

MBS540533

quantity :

0.1 mg Affinity-Puri

price :

390 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunoprecipitation, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS540533

products type :

Antibody

products full name :

TLR5 Antibody

products short name :

TLR5

products name syn :

SLEB1; TIL3; Toll like receptor 5; Toll/interleukin 1 receptor like protein 3 antibody

other names :

Toll-like receptor 5; Toll-like receptor 5; toll-like receptor 5; toll like receptor 5; Toll/interleukin-1 receptor-like protein 3

products gene name :

TLR5

other gene names :

TLR5; TLR5; SLE1; TIL3; SLEB1; MELIOS; TIL3

uniprot entry name :

TLR5_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Cat, Human, Mouse, Pig

sequence length :

858

form :

Affinity Purified

concentration :

0.75 ug/ul in antibody stabilization buffer

storage stability :

-20 degree C for long term storage

tested application :

ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)

app notes :

Dot Blot: 1:20,000. ELISA: 1:20,000. Immunoprecipitation: 1:200. Western Blot: 1:500

other info1 :

Immunogen: Synthetic peptide taken within amino acid region 195-225 on human TLR5 protein. Expression: Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.

other info2 :

Molecular Function: Receptor, interleukin-1 receptor binding, transmembrane signalling receptor activity. Structure: Binds MYD88 via their respective TIR domains (By similarity). Homodimer both in the absence and presence of ligand. Subcellular Location: Membrane; Single-pass type I membrane protein

products categories :

Primary Antibodies; Immunology; Innate Immunity; Macrophage / Inflammation; TLR5 Antibody

products description :

Affinity Purified Toll-like receptor 5 Antibody. Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.

ncbi gi num :

215274239

ncbi acc num :

O60602.4

uniprot acc num :

O60602

ncbi mol weight :

97,834 Da

ncbi pathways :

Disease Pathway (1268854); Diseases Associated With The TLR Signaling Cascade Pathway (1269157); Diseases Of Immune System Pathway (1269156); IRAK4 Deficiency (TLR5) Pathway (1269159); Immune System Pathway (1269170); Inflammatory Bowel Disease (IBD) Pathway (842771); Inflammatory Bowel Disease (IBD) Pathway (842797); Innate Immune System Pathway (1269203); Legionellosis Pathway (469200); Legionellosis Pathway (469186)

ncbi summary :

This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]

uniprot summary :

TLR5: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Genetic variation in TLR5 is associated with resistance to systemic lupus erythematosus type 1 (SLEB1). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Belongs to the Toll-like receptor family. Protein type: Receptor, misc.; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1q41-q42. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: interleukin-1 receptor binding; receptor activity; transmembrane receptor activity. Biological Process: defense response to Gram-negative bacterium; inflammatory response; innate immune response; male gonad development; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interleukin-8 production; positive regulation of nitric oxide biosynthetic process; positive regulation of toll-like receptor signaling pathway; regulation of cytokine secretion; toll-like receptor 5 signaling pathway. Disease: Legionnaire Disease, Susceptibility To; Melioidosis, Susceptibility To; Systemic Lupus Erythematosus, Susceptibility To, 1

size1 :

0.1 mg Affinity-Purified

price1 :

390 USD

more info or order :

MyBioSource product webpage