product summary
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company name :
MyBioSource
product type :
antibody
product name :
C6orf150 Antibody
catalog :
MBS540532
quantity :
0.1 mg Affinity-Puri
price :
390 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS540532
products type :
Antibody
products full name :
C6orf150 Antibody
products short name :
C6orf150
products name syn :
C6orf150; cGAMP synthase; cGAS; Chromosome 6 open reading frame 150; Cyclic GMP-AMP synthase; h-cGAS; Hypothetical protein LOC115004; Mab 21 domain containing 1; MB21D1; protein MB21D1; Uncharacterized protein C6orf150 antibody
other names :
cyclic GMP-AMP synthase; Cyclic GMP-AMP synthase; cyclic GMP-AMP synthase; Mab-21 domain containing 1; 2'3'-cGAMP synthase; Mab-21 domain-containing protein 1
other gene names :
MB21D1; MB21D1; cGAS; h-cGAS; C6orf150; C6orf150; cGAMP synthase; cGAS; h-cGAS
uniprot entry name :
CGAS_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Human
sequence length :
522
form :
Affinity Purified
concentration :
0.60 ug/ul in antibody stabilization buffer
storage stability :
-20 degree C for long term storage
tested application :
ELISA (EIA), Western Blot (WB)
app notes :
Dot Blot: 1:10,000. ELISA: 1:10,000. Western Blot: 1:500
other info1 :
Immunogen: Synthetic peptide taken within amino acid regions 350-450 on human cGAS protein. Expression: Is expressed in the monocytic cell line THP1 by type 1 Interferons
other info2 :
Determinant: N-epitope. Molecular Function: Nucleotidyltransferase; ATP binding; DNA binding. Structure: Monomer when in absence of DNA. Homodimer when bound to DNA. Subcellular Location: Cytoplasm; Cytosol
products categories :
Primary Antibodies; Signal Transduction; Second Messengers; cGMP; C6orf150 Antibody
products description :
Affinity Purified Cyclic GMP-AMP synthase Antibody N-epitope. Catalyzes the formation of cyclic GMP-AMP from ATP and GTP. Has antiviral activity through acting as a cystolic DNA senser.
ncbi gi num :
115511030
ncbi acc num :
NP_612450
ncbi gb acc num :
NM_138441.2
uniprot acc num :
Q8N884
ncbi mol weight :
49,762 Da
ncbi pathways :
Cytosolic DNA-sensing Pathway (125137); Cytosolic DNA-sensing Pathway (124833); Cytosolic Sensors Of Pathogen-associated DNA Pathway (1269268); Immune System Pathway (1269170); Innate Immune System Pathway (1269203); STING Mediated Induction Of Host Immune Responses Pathway (1269272)
uniprot summary :
MB21D1: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. Protein type: Enzyme, cellular metabolism; EC 2.7.7.86. Chromosomal Location of Human Ortholog: 6q13. Cellular Component: cytosol. Molecular Function: ATP binding; DNA binding; GTP binding; metal ion binding. Biological Process: activation of innate immune response; cyclic nucleotide biosynthetic process; defense response to virus; innate immune response; positive regulation of defense response to virus by host; positive regulation of interferon type I production
size1 :
0.1 mg Affinity-Purified
price1 :
390 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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