PBR Antibody | MyBioSource MBS540519 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PBR Antibody

catalog :

MBS540519

quantity :

0.1 mg Affinity-Puri

price :

390 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS540519

products type :

Antibody

products full name :

PBR Antibody

products short name :

PBR

products name syn :

Benzodiazapine receptor (peripheral); Benzodiazepine peripheral binding site; BPBS; BZRP; DBI; IBP; Isoquinoline carboxamide-binding protein; MBR; mDRC; Mitochondrial benzodiazepine receptor; PBR; PBS; Peripheral benzodiazepine receptor; Peripheral benzodiazepine receptor-related protein; pk18; PKBS; PTBR; Ptbzr; PTBZR02; RATPTBZR02; translocator protein (18kDa); Translocator protein; TSPO; Tspo1 antibody

other names :

Translocator protein; Translocator protein; translocator protein; translocator protein; Mitochondrial benzodiazepine receptor; PKBS; Peripheral-type benzodiazepine receptor; PBR

products gene name :

PBR

other gene names :

TSPO; TSPO; DBI; IBP; MBR; PBR; PBS; BPBS; BZRP; PKBS; PTBR; mDRC; pk18; BZRP; MBR; PBR

uniprot entry name :

TSPOA_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Rat

sequence length :

169

form :

Affinity Purified

concentration :

0.60-0.65 ug/ul in antibody stabilization buffer

storage stability :

-20 degree C for long term storage

tested application :

ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

app notes :

Dot Blot: 1:10,000. ELISA: 1:10,000. Immunohistochemistry: 1:100. Immunoprecipitation: 1:200. Western Blot: 1:500

other info1 :

Immunogen: Synthetic peptide taken within amino acid region 100-150 on 18 kDa mitochondrial benzodiazepine receptor protein. Expression: Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids

other info2 :

Molecular Function: Benzodiazepine receptor activity, cholesterol binding. Subcellular Location: Mitochondrian membrane, Multi-pass membrane protein

products categories :

Primary Antibodies; Cell Biology; Lipids; PBR Antibody

products description :

Affinity Purified Mitochondrial benzodiazepine receptor Antibody. Can bind protoporphyrin IX and may play a role in transport of porphyrins and heme. Promotes transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism.

ncbi gi num :

313104268

ncbi acc num :

P30536.3

uniprot acc num :

P30536

ncbi mol weight :

10,537 Da

ncbi summary :

Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein. [provided by RefSeq, Feb 2012]

uniprot summary :

TSPO: Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells. Belongs to the TspO/BZRP family. Interacts with BZRAP1. May interact with STAR. Interacts with MOST-1. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Apoptosis; Membrane protein, multi-pass; Receptor, misc.; Mitochondrial. Chromosomal Location of Human Ortholog: 22q13.31. Cellular Component: cytoplasm; integral to membrane; intracellular membrane-bound organelle; mitochondrial outer membrane; mitochondrion; nuclear membrane. Molecular Function: androgen binding; benzodiazepine receptor activity; cholesterol binding; protein binding. Biological Process: adrenal gland development; aging; anion transport; apoptosis; axon regeneration in the peripheral nervous system; behavioral response to pain; cell proliferation; chloride transport; glial cell migration; heme biosynthetic process; lipid transport; negative regulation of nitric oxide biosynthetic process; negative regulation of protein ubiquitination; negative regulation of tumor necrosis factor production; positive regulation of apoptosis; positive regulation of calcium ion transport; positive regulation of mitochondrial depolarization; protein targeting to mitochondrion; regulation of cholesterol transport; regulation of steroid biosynthetic process; response to drug; response to manganese ion; response to progesterone stimulus; response to testosterone stimulus; response to vitamin B1; steroid biosynthetic process; steroid metabolic process

size1 :

0.1 mg Affinity-Purified

price1 :

390 USD

more info or order :

MyBioSource product webpage