PREX1 Antibody | MyBioSource MBS540487 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PREX1 Antibody

catalog :

MBS540487

quantity :

0.1 mg Affinity-Puri

price :

390 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunoprecipitation, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS540487

products type :

Antibody

products full name :

PREX1 Antibody

products short name :

PREX1

products name syn :

4; 5)-dependent Rac exchanger 1; P REX1; PtdIns(3, 4, 5) dependent Rac exchanger 1; SET domain containing 6; Setd6 antibody

other names :

Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1

products gene name :

PREX1

other gene names :

PREX1; PREX1; P-REX1; KIAA1415; P-Rex1; PtdIns(3,4,5)-dependent Rac exchanger 1

uniprot entry name :

PREX1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

1659

form :

Affinity Purified

concentration :

0.6 ug/ul in antibody stabilization buffer

storage stability :

-20 degree C for long term storage

tested application :

ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)

app notes :

Dot Blot: 1:20,000-1:50,000. ELISA: 1:20,000-1:50,000. Immunoprecipitation: 1:500. Western Blot: 1:500-1:750

other info1 :

Immunogen: Synthetic peptide corresponding to aino acid region 815-836 of Human PREX1. Peptide was covalently modified. Sequence: QEEDQADSAFPLLSLGPRLSLC. Expression: Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.

other info2 :

Molecular Function: enzyme binding, Rho GTPase activator activity, Rho guanyl-nucleotide exchange factor activity, phospholipid binding. Subcellular Location: Cytoplasm, cell membrane

products categories :

Primary Antibodies; Signal Transduction; Guanylate Cyclases PREX1 Antibody

products description :

Affinity Purified Phosphatidylinositol 3, 4, 5-trisphosphate-dependent Rac exchanger 1 protein Antibody. Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3, 4, 5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.

ncbi gi num :

148886999

ncbi acc num :

Q8TCU6.3

uniprot acc num :

Q8TCU6

ncbi mol weight :

175,847 Da

ncbi pathways :

Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class I PI3K Signaling Events Pathway (138022); Regulation Of RAC1 Activity Pathway (169346)

ncbi summary :

The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008]

uniprot summary :

PREX1: Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. Interacts preferentially with RAC2. Interacts with RAC1. Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues. 3 isoforms of the human protein are produced by alternative splicing. Protein type: GEFs; GEFs, Rac/Rho. Chromosomal Location of Human Ortholog: 20q13.13. Cellular Component: cytoplasm; cytosol; dendritic shaft; growth cone; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane. Molecular Function: enzyme binding; GTPase activator activity; phospholipid binding; protein binding; Rho guanyl-nucleotide exchange factor activity. Biological Process: actin filament polymerization; G-protein coupled receptor protein signaling pathway; neutrophil activation; neutrophil chemotaxis; positive regulation of GTPase activity; regulation of actin filament polymerization; regulation of dendrite development; regulation of Rho protein signal transduction; superoxide metabolic process; T cell differentiation

size1 :

0.1 mg Affinity-Purified

price1 :

390 USD

more info or order :

MyBioSource product webpage