antibody

Rabbit Polyclonal Anti-Myocilin Antibody

MBS540475

0.1 mg

390 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, enzyme immunoassay

Antibody

Rabbit Polyclonal Anti-Myocilin Antibody

[Myocilin]

[Glaucoma 1 open angle; GLC1A; GPOA; JOAG; Mutated trabecular meshwork-induced glucocorticoid response protein; MYOC; Myocilin; TIGR antibody]

[myocilin; Myocilin; Myocilin, N-terminal fragmentAlternative name(s):Myocilin 20 kDa N-terminal fragment]

[MYOC; ]

MYOC_HUMAN

Polyclonal

Rabbit

Human, Monkey, Mouse, Rat

490

Affinity purified immunoglobulins

0.72 ug/ul IgG in antibody stabilization buffer

Store at -20 degree C for long term storage

ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunomicroscopy (IM), Western Blot (WB)

Dot Blot: 1:10,000. ELISA: 1:10,000. Immunocytochemistry: 1:200. Immunofluorescence: 1:200. Immunohistochemistry: 1:200. Immunoprecipitation: 1:200. Western Blot: 1:500

Western Blot (WB)

Immunogen: Synthetic peptide corresponding to N terminal amino acids 25-46 of Myocilin. Peptide was covalently modified and conjugated to KLH.

Primary Antibodies; Neuroscience; Sensory Systems; Vision; Myocilin Antibody

2828346

BAA24532.1

Q99972

Predicted: 55 kDa.

MYOC: May participate in the obstruction of fluid outflow in the trabecular meshwork. Defects in MYOC are the cause of primary open angle glaucoma type 1A (GLC1A). Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place. Defects in MYOC are a cause of primary congenital glaucoma type 3A (GLC3A). An autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early choldhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor. MYOC variations may contribute to GLC3A via digenic inheritance with CYP1B1 and/or another locus associated with the disease. Protein type: Endoplasmic reticulum; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1q23-q24. Cellular Component: cilium; cytoplasmic membrane-bound vesicle; cytoplasmic vesicle; endoplasmic reticulum; extracellular matrix; extracellular space; Golgi apparatus; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial outer membrane; proteinaceous extracellular matrix; rough endoplasmic reticulum. Molecular Function: fibronectin binding; frizzled binding; metal ion binding; myosin light chain binding; protein binding; receptor tyrosine kinase binding. Biological Process: clustering of voltage-gated sodium channels; myelination in the peripheral nervous system; negative regulation of cell-matrix adhesion; negative regulation of Rho protein signal transduction; negative regulation of stress fiber formation; neurite development; osteoblast differentiation; positive regulation of cell migration; positive regulation of focal adhesion formation; positive regulation of mitochondrial depolarization; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of stress fiber formation; regulation of MAPKKK cascade; skeletal muscle hypertrophy. Disease: Glaucoma 1, Open Angle, A

0.1 mg

390 USD