antibody

Phospho Slingshot homolog 1 Antibody

MBS540364

0.1 mg Affinity-Puri

495 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, enzyme immunoassay

Antibody

Phospho Slingshot homolog 1 Antibody

Phospho-Slingshot homolog 1

AW551225; Coro1c; coronin, actin binding protein 1C; Gm1394; Gm1395; Protein phosphatase Slingshot homolog 1; slingshot like 1; SSH1 antibody

protein phosphatase Slingshot homolog 1 isoform 1; Protein phosphatase Slingshot homolog 1; protein phosphatase Slingshot homolog 1; slingshot protein phosphatase 1; SSH-like protein 1; SSH-1L; hSSH-1L

SSH1; SSH1; SSH1L; KIAA1298; SSH1L; SSH-1L; hSSH-1L

SSH1_HUMAN

Polyclonal

Rabbit

Human, Monkey, Mouse, Rat

1049

Affinity Purified

0.64-0.72 ug/ul in antibody stabilization buffer

-20 degree C for long term storage

ELISA (EIA), Western Blot (WB)

Dot Blot: 1:10,000. ELISA: 1:10,000. Western Blot: 1:500

Immunogen: Phosphorylated synthetic peptide corresponding to unique amino acid sequence on Slingshot homolog 1 protein.

Modification: Phosphorylated. Molecular Function: Hydrolase, protein phosphatase. Subcellular Location: Cytoplasm, cytoskeleton, cell projection, lamellipodium, cleavage furrow, midbody. (Note: Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at site of cell locomotion. Also localized to

Primary Antibodies; Signal Transduction; Protein Phosphatases; Phospho-Slingshot homolog 1 Antibody

Affinity Purified Phosphorylated Protein phosphatase Slingshot homolog 1 Antibody. Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.

239047414

NP_061857.3

NM_018984.3

Q8WYL5

78,978 Da

Axon Guidance Pathway (83065); Axon Guidance Pathway (476); CXCR4-mediated Signaling Events Pathway (137910); FGF Signaling Pathway (137989); Regulation Of Actin Cytoskeleton Pathway (198874); Regulation Of Actin Cytoskeleton Pathway (83089); Regulation Of Actin Cytoskeleton Pathway (500)

The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

SSH1: a dual-specificity phosphatase of the Slingshot family involved in actin reorganization. Its calcineurin-dependent activation dephosphorylates cofilin. Plays a role in later stages of mitosis by dephosphorylating and activating cofilin. Protein type: EC 3.1.3.16; EC 3.1.3.48; Protein phosphatase, dual-specificity. Chromosomal Location of Human Ortholog: 12q24.11. Cellular Component: cleavage furrow; cytoplasm; cytoskeleton; lamellipodium; midbody; nucleoplasm; plasma membrane. Molecular Function: actin binding; DNA binding; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity. Biological Process: actin cytoskeleton organization and biogenesis; cell morphogenesis; protein amino acid dephosphorylation; regulation of actin polymerization and/or depolymerization; regulation of axonogenesis; regulation of cellular protein metabolic process

0.1 mg Affinity-Purified

495 USD