antibody

LILRB3 Antibody

MBS540248

0.1 mg Affinity-Puri

390 USD

polyclonal

rabbit

nonconjugated

mouse, rat

western blot, ELISA

Antibody

LILRB3 Antibody

LILRB3

CD85 antigen like family member A; HL9; IL T5; Immunoglobulin like transcript 5; LIR 3; MGC138403; Monocyte inhibitory receptor HL9; PIRB antibody

leukocyte immunoglobulin-like receptor subfamily B member 3; Leukocyte immunoglobulin-like receptor subfamily B member 3; leukocyte immunoglobulin-like receptor subfamily B member 3; paired Ig-like receptor B; Cell-surface glycoprotein p91; Paired immunoglobulin-like receptor B; PIR-B

LILRB3

Pirb; Lilrb3; Gp91; LIR-3; PIR-B; Lilrb3; Pirb; LIR-3; Leukocyte immunoglobulin-like receptor 3; PIR-B

LIRB3_MOUSE

Polyclonal

Rabbit

Mouse, Rat

841

Affinity Purified Immunoglobulins

0.74 ug/ul in antibody stabilization buffer

Store at -20 degree C for long term storage.

ELISA, Western Blot (WB), Dot Blot (DB)

Dot Blot: 1:20,000. ELISA: 1:20,000. Western Blot: 1:500. Other applications and species cross reactivity for this antibody is yet to be determined.

Immunogen: Synthetic peptide corresponding to unique amino acid sequence on mouse LILRB3 protein. Alternative Nomenclature: CD85 antigen like family member A antibody HL9 antibody IL T5 antibody Immunoglobulin like transcript 5 antibody LIR 3 antibody , MGC138403 antibody Monocyte inhibitory receptor HL9 antibody PIRB antibody. Determinant: N-epitope

Primary Antibodies; Immunology; Adaptive Immunity; MHC; LILRB3 Antibody

Leukocyte Ig-like receptors (LILRs) are the mammalian ortholog of Paired Ig-like Receptors (PirB) receptors which are encoded by several genes and are expressed on various immune cells from myeloid and lymphoid lineages (1). LILRs are divided into two types of receptors: activating-type receptors and inhibitory-type. LILRB receptor genes are located on chromosomal region 19q13.4 which encode 19 genes encoding leukocyte-expressed receptors of the immunoglobulin (Ig) superfamily. LIRs contain either two or four Ig domains and fall into three classes: (i) those with cytoplasmic domains containing two, three, or four immunoreceptor tyrosine-based inhibitory motif-like motifs; (ii) those with a short cytoplasmic domain and no immunoreceptor tyrosine-based inhibitory motif-like motifs; and (iii) those with no transmembrane domain represented by a single LILR molecule that is presumably secreted. LILRB3 receptors are expressed in at least 3 variant isoforms (isoform 1, 2 and 3) with molecular weight around 76-78kDa. The amino acid sequences in the extracellular regions of eight of these receptors show between 63 and 84% identity to the prototypic LILR1. The LILRB3 selective antibodies were made against an epitope that corresponds to amino acids ranging from 615-632 from human LILRB3 protein. The antibodies are affinity purified on an immobilized antigen based affinity matrix. The isolated antibodies were then stabilized in antibody stabilization buffer for long-term storage.

160333134

NP_035225.2

NM_011095.2

P97484

93,054 Da

B Cell Receptor Signaling Pathway (83278); B Cell Receptor Signaling Pathway (492); Osteoclast Differentiation Pathway (193149); Osteoclast Differentiation Pathway (193096); Spinal Cord Injury Pathway (739004)

Pirb: May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B- cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). Protein type: Membrane protein, integral. Cellular Component: integral to membrane; membrane; plasma membrane. Biological Process: adaptive immune response; B cell homeostasis; B cell mediated immunity; cytokine and chemokine mediated signaling pathway; immune system process; myeloid dendritic cell differentiation

0.1 mg Affinity-Purified

390 USD