antibody

BACE2 B Antibody

MBS540140

0.1 mg

390 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunoprecipitation, enzyme immunoassay

Antibody

BACE2 B Antibody

[BACE2 B]

[ALP 56; ASP1; ASP21; Aspartic Like Protease 56kDa; Downs Syndrome Region Aspartic Protease; DRAP; Memapsin-1; Membrane associated aspartic protease 1; Theta-secretase antibody]

[beta-secretase 2 isoform B preproprotein; Beta-secretase 2; beta-secretase 2; beta-site APP-cleaving enzyme 2; Aspartic-like protease 56 kDa; Aspartyl protease 1; ASP1; Asp 1; Beta-site amyloid precursor protein cleaving enzyme 2; Beta-site APP cleaving enzyme 2; Down region aspartic protease; DRAP; Memapsin-1; Membrane-associated aspartic protease 1; Theta-secretase]

[BACE2 B]

[BACE2; BACE2; ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1; AEPLC; ALP56; ASP21; ASP1; Asp 1; Beta-site APP cleaving enzyme 2; DRAP]

BACE2_HUMAN

Polyclonal

Rabbit

Human, Monkey

396

Affinity Purified

0.55-0.59 ug/ul in antibody stabilization buffer

-20 degree C for long term storage

ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)

Dot Blot: 1:10,000. ELISA: 1:10,000. Western Blot: 1:500

Western Blot (WB)

Immunogen: Synthetic peptide taken within amino acid region 350-396 on human BACE2B protein. Expression: Neurons within the hippocampus, frontal cortex and temporal cortex. Lower expression in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Also found in spinal cord, medulla oblongata, substania nigra and locus coruleus. Expressed in ductal epithelium of prostate.

Molecular Function: Aspartic-type endopeptidase activity. Structure: Belongs to the peptidase A1 family. Subcellular Location: Endoplasmic Reticulum, Endosome, Golgi apparatus; Membrane

Primary Antibodies; Neuroscience; Neurogenesis & Plasticity; BACE2 B Antibody

Affinity Purified beta-secretase 2 isoform B preproprotein Antibody. Responsible for the proteolytic processing of the amyloid precursor protein. Cleaves APP between 690 and 691 leading to the generation and extracellular release of beta-cleaved soluble APP and C-terminal fragment which is later released by gamma-secretase.

21040362

NP_620477

NM_138992.2

Q9Y5Z0

46,476 Da

Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509)

This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

BACE2: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C- terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Belongs to the peptidase A1 family. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Protease; EC 3.4.23.45; Membrane protein, integral. Chromosomal Location of Human Ortholog: 21q22.3. Cellular Component: cell surface; endoplasmic reticulum; endosome; Golgi apparatus; integral to membrane. Molecular Function: aspartic-type endopeptidase activity; beta-amyloid binding. Biological Process: beta-amyloid metabolic process; membrane protein ectodomain proteolysis; negative regulation of amyloid precursor protein biosynthetic process; peptide hormone processing; protein catabolic process; proteolysis

0.1 mg

390 USD