antibody

C6orf150 Antibody

MBS540138

0.1 mg Affinity-Puri

425 USD

polyclonal

rabbit

nonconjugated

mouse, rat

western blot, ELISA, immunohistochemistry, immunoprecipitation, enzyme immunoassay

Antibody

C6orf150 Antibody

C6orf150

C6orf150; cGAMP synthase; cGAS; Chromosome 6 open reading frame 150; Cyclic GMP-AMP synthase; h-cGAS; Hypothetical protein LOC115004; Mab 21 domain containing 1; MB21D1; protein MB21D1; Uncharacterized protein C6orf150 antibody

cyclic GMP-AMP synthase; Cyclic GMP-AMP synthase; cyclic GMP-AMP synthase; Mab-21 domain containing 1; 2'3'-cGAMP synthase; Mab-21 domain-containing protein 1

Mb21d1; Mb21d1; cGAS; E330016A19Rik; cGAMP synthase; cGAS; m-cGAS

CGAS_MOUSE

Polyclonal

Rabbit

Mouse, Rat

507

Affinity Purified

0.60 ug/ul in antibody stabilization buffer

-20 degree C for long term storage

ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

Dot Blot: 1:10,000. ELISA: 1:10,000. Immunoprecipitation: 1:150. Western Blot: 1:500

Immunogen: Synthetic peptide taken within amino acid region 450-500 on mouse cGAS protein. Expression: Is expressed in the monocytic cell line THP1 by type 1 Interferons

Molecular Function: Nucleotidyltransferase; ATP binding; DNA binding. Structure: Monomer when in absence of DNA. Homodimer when bound to DNA. Subcellular Location: Cytoplasm; Cytosol

Primary Antibodies; Signal Transduction; Second Messengers; cGMP; C6orf150 Antibody

Affinity Purified Cyclic GMP-AMP synthase Antibody. Catalyzes the formation of cyclic GMP-AMP from ATP and GTP. Has antiviral activity through acting as a cystolic DNA senser.

116812912

NP_775562

NM_173386.5

Q8C6L5

58,194 Da

Cytosolic DNA-sensing Pathway (125146); Cytosolic DNA-sensing Pathway (124833)

The protein encoded by this gene is a DNA binding cytosolic protein that catalyzes the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) after sensing the presence of DNA in the cytoplasm. cGAMP binds another protein, Stimulator of interferon genes (STING), leading to the induction of interferons, and a host immune response. Reduced expression of this gene inhibits interferon induction in the presence of some viral infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

MB21D1: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. Protein type: Enzyme, cellular metabolism; EC 2.7.7.86. Cellular Component: cytoplasm; cytosol. Molecular Function: ATP binding; DNA binding; GTP binding; metal ion binding; nucleotide binding; nucleotidyltransferase activity; transferase activity. Biological Process: activation of innate immune response; cyclic nucleotide biosynthetic process; defense response to virus; immune system process; innate immune response; positive regulation of defense response to virus by host

0.1 mg Affinity-Purified

425 USD