product summary
Loading...
company name :
MyBioSource
product type :
antibody
product name :
TICAM2 Antibody Affinity Purified
catalog :
MBS540128
quantity :
0.1 mg Affinity-Puri
price :
425 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
application :
western blot, ELISA, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS540128
products type :
Antibody
products full name :
TICAM2 Antibody Affinity Purified
products short name :
TICAM2
products name syn :
Putative NF-kappa-B-activating protein 502; TICAM2; TIR containing adapter molecule 2; TIR domain-containing adapter molecule 2; TIRAP3; TIRP; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein; TRAM; TRIF-related adapter molecule antibody
other names :
TRIF-related adapter molecule; TIR domain-containing adapter molecule 2; Putative NF-kappa-B-activating protein 502; TRIF-related adapter molecule; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein; MyD88-4
products gene name :
TICAM2
other gene names :
TICAM2; TIRAP3; TIRP; TRAM; TICAM-2; MyD88-4
uniprot entry name :
TCAM2_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
235
form :
Affinity Purified
concentration :
0.50-0.75 ug/ul in antibody stabilization buffer
storage stability :
-20 degree C for long term storage
tested application :
Dot Blot (DB), ELISA (EIA), Western Blot (WB)
app notes :
Dot Blot: 1:20,000. ELISA: 1:20,000. Western Blot: 1:500-1:750
other info1 :
Immunogen: Synthetic peptide corresponding to unique amino acid sequences on TRIF-related adapter molecule. Expression: Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1).
other info2 :
Molecular Function: phospholipid binding, signal transducer activity. Structure: Homodimer. Interacts with TLR4, TICAM1, IRF3 and IRF7 in response to LPS. Interacts with IL1R1, IL1RAP, IRAK2, IRAK3 and TRAF6. Interacts with protein kinase-inactive mutants of IRAK1 and IRAK4. Isoform 1 interacts with isoform 2; the interaction occurs i. Subcellular Location: Isoform 1 : Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic Reticulum. Early endosome membrane. Late endosome membrane, Isoform 2 : Endoplasmic Reticulum. Early endosome membrane. Late endosome membrane, Isoform 2 : Endoplasmic Reticulum. Early end
products categories :
Primary Antibodies; Immunology; Innate Immunity; TLR Signaling; TICAM2 Antibody
products description :
Affinity Purified TRIF-related adapter molecule Antibody. Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.
ncbi gi num :
29470173
ncbi acc num :
AAO74498.1
uniprot acc num :
Q86XR7
ncbi mol weight :
46,173 Da
size1 :
0.1 mg Affinity-Purified
price1 :
425 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

Would you like to receive email and e-newsletter from MyBioSource about new products, special offers and events? Please click here to join our Mailing List!