Thickvein C | MyBioSource MBS540123 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Thickvein C

catalog :

MBS540123

quantity :

0.1-0.15 ml WB Contr

price :

290 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

fruit fly

application :

western blot, immunoprecipitation

product information

catalog number :

MBS540123

products type :

Antibody

products full name :

Thickvein C

products short name :

Thickvein C

products name syn :

Anti-Thickvein type C antibodies (TkvC-301AP

other names :

thickveins, isoform C; Thick veins protein; CG14026 gene product from transcript CG14026-RA; Activin-A-receptor-25D; BMP receptor kinase 25D; CG14026-PA; CG14026-PB; CG14026-PC; CG14026-PD; DPP receptor; Thick-vein; slater; thick veins; thickvein; thickveins; tkv-PA; tkv-PB; tkv-PC; tkv-PD; thickveins

other gene names :

tkv; tkv; Atkv; Atr25D; Brk25D; Brk25D1; Brk25D2; CG14026; DmelCG14026; dtfr; Dtfr; kv; l(2)04415; l(2)25Da; STK-A; str; Tkv; TKV; tkv1; TKV1; tkva

uniprot entry name :

Q7KTP1_DROME

clonality :

Polyclonal

host :

Rabbit

reactivity :

Drosophila Melanogaster

purity :

Affinity purifed

concentration :

~0.5mg/ml

storage stability :

Shipped at 4 degree C. Store at -20 degree C

tested application :

Western Blot (WB), Immunoprecipitation (IP)

app notes :

Antibody is ideal for WB, other applications are not yet determined. The dilutions for this antibody is for reference only, investigators are expected to determine the optimal conditions for specific assay in his/her laboratory. All Tkvc-301AP antibodies work well in Western analyses. Western blotting: > 1:500; Immunoprecipitation & i.p pull-down assays: n.d

other info1 :

Immunogen: peptide

other info2 :

Preservatives: 0.02% Na3N. Buffer: PO4-buffer/Tris/Glycine, pH 7.4-7.8. PO4-buffer/Tris/Glycine, pH 7.4-7.8

products categories :

D. melanogaster protein Decapentaplegic ligand Receptor Thickvein selective antibodies

products description :

Fruit fly (Drosophila melanogaster) ovaries contains two set of germline stem cells surrounded by a group of highly differentiated somatic cells that express genes for two phenotypes (hedgehog & wingless). The TGF beta super family member, decpentaplegic (dpp) or its homologue BMP2/4 is specifically required for maintenance and promote its cell division in the female germline (1, 2). The Signaling by TGF beta-related factors requires ligand-induced association between type I and type II transmembrane receptors that have endogenous serine/threonine kinases activity. In Drosophila, thickveins (tkv) and saxophone (sax) genes encode type I receptors that mediate signaling by decapentaplegic (dpp), a member of the bone morphogenetic protein (BMP) subgroup of TGF beta-type factors. Patterning the dorsal surface of fruitfly blastoderm embryo requires Decapentaplegic (Dpp) and Screw (Scw), two BMP family members. The signaling by these ligands is mediated by Bone morphogenentic protein (BMP) binding proteins Sog and Tsg. It is demonstrated that Tsg and Sog play essential role in transport of heterodimer Dpp/Sog signaling through the two type I BMP receptors Tkv and SAX (3). Over expression or mutation in dpp suppress germline stem cell differentiation. Dpp actions are mediated by its receptor Saxophone. The Saxophone gene is expressed ubiquitously. The Saxophone gene also gives two products Brk43E and Berk25 and both gene products inter acts with TGF super family peptide ligands Dpp. Mutations that completely abolish Saxophone activity causes phenotype that are similar to partial or complete loss of activity of the dpp ligand. The saxophone products are also have serine threonine kinase activity responsible for phsosphorylation and activation of the ligands including pMAD, Screw (Scw), and short gastrulation protein (Sog). At least 4 different Tkv variants are cloned so far (Tkv A, Tkv B, Tkv C and Tkv D). The anti-Thickvein C-selective antibodies were generated against conserved sequences near the N-terminus of the protein that are common in all the Thickvein variants. The Tkv-selective antibodies are affinity purified against immobilized antigen based affinity chromatography which yielded epitope-specific antibodies. The Tkv antibodies label 68-69kDa proteins in D. melanogaster extracts. Anti-Tkv-selective antibodies are also available in affinity-purified form for confocal, Western blotting and immunocytochemical analyses. MyBioSource will also conjugate antibodies with fluorescent probes upon request at extra charge. MyBioSource also provides several antibodies against proteins that are involved cell cycle and differentiation. A list of these antibodies can be viewed from www.mybiosource.com. MyBioSource employs cyclic peptide methodology for generating antibodies, which results in higher titer and specificity. MyBioSource, will also provide Western blot positive controls for most of these antibodies in ready-to-use buffer for easy identification of respective proteins. Limited quantities of antigenic blocking peptides are also available. Please inquire for their availability before ordering.

ncbi gi num :

28574648

ncbi acc num :

NP_787990

ncbi gb acc num :

NM_175976.1

uniprot acc num :

Q7KTP1

ncbi mol weight :

62,748 Da

ncbi pathways :

Signal Transduction Pathway 824028!!Signaling By BMP Pathway 824093!!TGF-beta Signaling Pathway 3098!!TGF-beta Signaling Pathway 475

size :

0.1-0.15 ml WB Control

price :

290 USD