Stra6 Antibody | MyBioSource MBS540120 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Stra6 Antibody

catalog :

MBS540120

quantity :

0.1 mg Affinity-Puri

price :

390 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunoprecipitation, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS540120

products type :

Antibody

products full name :

Stra6 Antibody

products short name :

Stra6

products name syn :

MCOPCB8; MCOPS9; PP14296; Stimulated by retinoic acid 6 homolog; Stimulated by retinoic acid gene 6 protein homolog; STRA6 antibody

other names :

unnamed protein product; Stimulated by retinoic acid gene 6 protein; stimulated by retinoic acid gene 6 protein homolog; stimulated by retinoic acid 6; Retinoic acid-responsive protein

products gene name :

Stra6

other gene names :

STRA6; Stra6; MCOPS9; MCOPCB8; PP14296

uniprot entry name :

STRA6_MOUSE

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Monkey

sequence length :

560

form :

Affinity Purified

concentration :

0.69 ug/ul in antibody stabilization buffer

storage stability :

-20 degree C for long term storage

tested application :

ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)

app notes :

Dot Blot: 1:10,000. ELISA: 1:10,000. Immunoprecipitation: 1:200. Western Blot: 1:500

other info1 :

Immunogen: Synthetic peptide taken within third large intra cytoplasmic loop within amino acid region 450-500 on human Stra6 protein. Expression: Widely expressed in the embryo. In the adult, is highly expressed in cells that compose blood-organ barriers in the brain (choroid plexus and the brain microvascular), in the eye (retinal pigment epithelium), in testis (the basal layer of the seminiferous epithelium), in the yolk sac, and in the chorioallantoic placenta (at protein level). Also detected in kidney, spleen, and female genital tract; and at lower levels in heart and lung.

other info2 :

Molecular Function: Receptor, Receptor activity. Subcellular Location: Cell membarane; Multi-pass membrane protein

products categories :

Primary Antibodies; Cell Biology; Developmental Biology; Lineage specification; Endoderm; Stra6 Antibody

products description :

Affinity Purified Retinoic acid-responsive protein Antibody. May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity.

ncbi gi num :

10434086

ncbi acc num :

BAB14122.1

uniprot acc num :

O70491

ncbi mol weight :

73,775 Da

ncbi pathways :

Disease Pathway (1268854); Diseases Associated With Visual Transduction Pathway (1268929); Diseases Of Signal Transduction Pathway (1268855); Retinoid Cycle Disease Events Pathway (1268930); Signal Transduction Pathway (1269379); The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway (1269625); Visual Phototransduction Pathway (1269623)

ncbi summary :

The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

uniprot summary :

STRA6: May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex. Defects in STRA6 are the cause of microphthalmia syndromic type 9 (MCOPS9); also called Matthew-Wood syndrome or Spear syndrome. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS9 is a rare clinical entity including as main characteristics anophthalmia or severe microphthalmia, and pulmonary hypoplasia or aplasia. Mutations in STRA6 may be a cause of isolated colobomatous microphthalmia, a disorder of the eye characterized by an abnormally small ocular globe. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; Membrane protein, integral. Cellular Component: integral to membrane; membrane; plasma membrane; protein complex. Molecular Function: protein binding; receptor activity; vitamin transporter activity. Biological Process: adrenal gland development; alveolus development; artery morphogenesis; blood vessel development; cognition; developmental growth; digestive tract morphogenesis; ear development; embryonic gut development; feeding behavior; female genitalia development; heart development; kidney development; learning; lung development; neuromuscular process; nose morphogenesis; positive regulation of behavior; positive regulation of JAK-STAT cascade; smooth muscle development; transport; vocal learning

size1 :

0.1 mg Affinity-Purified

price1 :

390 USD

more info or order :

MyBioSource product webpage