catalog number :
MBS540114
products full name :
Soluble Guanylyl Cyclase alpha 1 Antibody
products short name :
Guanylyl Cyclase alpha 1
products name syn :
GC S alpha 1; Guanylate cyclase soluble subunit alpha 1; Gucy1a1; Soluble guanylate cyclase large subunit antibody
other names :
guanylyl cyclase alpha 1 subunit; Guanylyl cyclase alpha 1 subunit; guanylate cyclase soluble subunit alpha-3; guanylate cyclase 1, soluble, alpha 3; Guanylyl cyclase alpha 1 subunit
other gene names :
Gucy1a3; Gucy1a3; SGC; Gucy1a1
uniprot entry name :
Q8CJD2_RAT
reactivity :
Human, Mouse, Rat
concentration :
0.7 ug/ul in antibody stabilization buffer
storage stability :
-20 degree C for long term storage
tested application :
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
app notes :
Dot Blot: 1:10,000. ELISA: 1:10,000. Western Blot: 1:500
other info1 :
Immunogen: Synthetic peptide taken within amino acid region 654-704 on rat Guanylyl cyclase alpha 1 subunit protein.
other info2 :
Molecular Function: guanylate cyclase activity, heme binding, nucleotide binding
products categories :
Primary Antibodies; Signal Transduction; Second Messengers; cGMP; Soluble Guanylyl Cyclase alpha 1 Antibody
ncbi acc num :
BAC24016.1
ncbi mol weight :
79,188 Da
ncbi pathways :
Circadian Entrainment Pathway (698787); Circadian Entrainment Pathway (699872); Gap Junction Pathway (83464); Gap Junction Pathway (483); Hemostasis Pathway (1376390); Long-term Depression Pathway (83478); Long-term Depression Pathway (497); Myometrial Relaxation And Contraction Pathways (198465); Nitric Oxide Stimulates Guanylate Cyclase Pathway (1376393); Oxytocin Signaling Pathway (953613)
ncbi summary :
soluble guanylate cyclase subunit that forms a heterodimer with Gucy1b3; may also function as an intracellular nitric oxide receptor [RGD, Feb 2006]
uniprot summary :
GUCY1A3: Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]. Protein type: Guanylyl cyclase; Receptor, misc.; EC 4.6.1.2; Nucleotide Metabolism - purine; Lyase. Cellular Component: cytosol; guanylate cyclase complex, soluble; plasma membrane; protein complex. Molecular Function: adenylate cyclase activity; cytidylate cyclase activity; GTP binding; guanylate cyclase activity; heme binding; ion binding; nucleotide binding; protein heterodimerization activity. Biological Process: cAMP biosynthetic process; cGMP biosynthetic process; nitric oxide mediated signal transduction; positive regulation of cGMP biosynthetic process; regulation of blood pressure; relaxation of vascular smooth muscle; response to defense-related host nitric oxide production; response to herbicide; response to organic cyclic substance
size1 :
0.1 mg Affinity-Purified