catalog number :
MBS540111
products full name :
DNA polymerase eta Antibody Affinity Purified
products short name :
DNA polymerase eta
products name syn :
DNA polymerase eta; FLJ16395; FLJ21978; POLH; polymerase DNA directed eta; RAD30; RAD30 homolog A; Xeroderma pigmentosum variant type protein; XPV antibody
other names :
Chain A, Yeast Dna Polymerase Eta; DNA polymerase eta; Radiation-sensitive protein 30
other gene names :
RAD30; DBH1
uniprot entry name :
POLH_YEAST
reactivity :
Saccharomyces cerevisae
concentration :
0.70-0.98 ug/ul in antibody stabilization buffer
storage stability :
-20 degree C for long term storage
tested application :
ELISA (EIA), Western Blot (WB)
app notes :
Dot Blot: 1:10,000. ELISA: 1:10,000. Western Blot: 1:500
other info1 :
Immunogen: Synthetic peptide taken within amino acid region 200-300 on Chain A, Yeast DNA polymerase Eta. Expression: Induced by UV radiation and heat shock. The mRNA is stabilized during stationary phase.
other info2 :
Molecular Function: Damaged DNA binding, Metal ion binding, DNA-directed DNA polymerase activity. Structure: Interacts with POL30. This interaction is essential for the polymerase eta function. Subcellular Location: Nucleus
products categories :
Primary Antibodies; Epigenetics; DNA polymerase eta Antibody
products description :
Affinity Purified Chain B, Yeast DNA polymerase Eta Antibody. DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. Efficiently incorporates nucleotides opposite to other UV or oxidative DNA damages like O(6)-methylguanine, 7, 8-dihydro-8-oxoguanine, 2, 6-diamino-4-hydroxy-5-formamidopyrimidine of 2'-deoxyguanosine (FaPydG), or p-benzoquinone DNA adducts.
ncbi mol weight :
71,515 Da
size1 :
0.1 mg Affinity-Purified