antibody

PGCA Antibody

MBS540089

0.1 mg Affinity-Puri

425 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, enzyme immunoassay

Antibody

PGCA Antibody

PGCA

ANP A; Atrial natriuretic peptide A type receptor; Atrial natriuretic peptide receptor 1; GC A; GC-A; Guanylate cyclase A; NPR 1; NPR A antibody

Atrial natriuretic peptide receptor 1; Atrial natriuretic peptide receptor 1; atrial natriuretic peptide receptor 1; natriuretic peptide receptor 1; Atrial natriuretic peptide receptor type A; ANP-A; ANPR-A; NPR-A; Guanylate cyclase A; GC-A

PGCA

NPR1; NPR1; ANPa; NPRA; ANPRA; GUC2A; GUCY2A; ANPRA; ANP-A; ANPR-A; NPR-A; GC-A

ANPRA_HUMAN

Polyclonal

Rabbit

Human, Mouse, Rat

1061

Will label a 127 to 130 kDa protein in various tissues. Will label only PGCA, but not other Particulate Guanylate Cyclases.

Affinity Purified

0.85 ug/ul in antibody stabilization buffer

-20 degree C for long term storage

Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

Confocal Microscopy 1:25-1:250. Dot Blot: 1:10,000. ELISA: 1:10,000. Immunocytochemistry: 1:25-1:250. Immunofluorescence: 1:25-1:250. Immunohistochemistry: 1:25-1:250. Immunoprecipitation: 1:200. Western Blot: 1:500

Immunogen: Synthetic peptide corresponding to C terminal amino acids 1042-1057 of Human PGCA. Seqence:. VRTYWLLGERGCSTRG

Molecular Function: ATP binding, GTP binding, hormone binding, Protein kinase activity, G-protein coupled peptide receptor activity. Structure: Homodimer. Subcellular Location: Membrane; Single-pass type I membrane protein

Primary Antibodies; Signal Transduction; Second Messengers; cGMP; PGCA Antibody

Affinity Purified Atrial natriuretic peptide receptor 1 Antibody. Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.

113912

P16066.1

P16066

118,919 Da

Aldosterone Synthesis And Secretion Pathway (1272485); Aldosterone Synthesis And Secretion Pathway (1285075); Cardiac Conduction Pathway (1339115); Muscle Contraction Pathway (1269868); Oxytocin Signaling Pathway (952859); Oxytocin Signaling Pathway (960764); Physiological Factors Pathway (1339122); Purine Metabolism Pathway (82944); Purine Metabolism Pathway (307); Regulation Of Lipolysis In Adipocytes Pathway (1222950)

Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM, May 2009]

ANPA: natriuretic peptide receptor A, which mediates natriuretic, diuretic, and vasorelaxing actions of the natriuretic peptides. Contains five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Has guanylate cyclase activity on binding of ANF. Hypertensive SHR Rat has polymorphism at the locus. Human non-coding polymorphisms can alter expression up to two-fold, and have been associated with hypertension. A coding SNP is associated with hypertension and myocardial infarction. Protein type: Guanylyl cyclase; Protein kinase, RGC; Lyase; Protein kinase, dual-specificity (receptor); Nucleotide Metabolism - purine; Kinase, protein; EC 4.6.1.2; Receptor, misc.; Membrane protein, integral; RGC group; RGC family. Chromosomal Location of Human Ortholog: 1q21-q22. Cellular Component: guanylate cyclase complex, soluble; integral to plasma membrane; plasma membrane; receptor complex. Molecular Function: adenylate cyclase activity; ATP binding; GTP binding; guanylate cyclase activity; hormone binding; natriuretic peptide receptor activity; peptide hormone binding; peptide receptor activity, G-protein coupled; protein kinase activity; protein kinase binding. Biological Process: body fluid secretion; cell surface receptor linked signal transduction; cGMP biosynthetic process; dopamine metabolic process; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; negative regulation of cell growth; negative regulation of smooth muscle cell proliferation; positive regulation of cGMP biosynthetic process; protein amino acid phosphorylation; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; regulation of vascular permeability; regulation of vasodilation

0.1 mg Affinity-Purified

425 USD