antibody

ILK Antibody Affinity Purified

MBS540038

0.1 mg Affinity-Puri

390 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, enzyme immunoassay

Antibody

ILK Antibody Affinity Purified

Integrin linked ILK

59 kDa serine/threonine protein kinase; DKFZp686F1765; ILK 1; ILK 2; ILK; Integrin linked kinase 2; Integrin-linked protein kinase; p59; p59ILK antibody

Integrin-linked protein kinase; Integrin-linked protein kinase; integrin-linked protein kinase; integrin linked kinase; 59 kDa serine/threonine-protein kinase; ILK-1; ILK-2; p59ILK

ILK

ILK; ILK; P59; ILK-1; ILK-2; p59ILK; HEL-S-28; ILK1; ILK2

ILK_HUMAN

Polyclonal

Rabbit

Human, Mouse, Rat

452

Affinity Purified

0.66-0.87 ug/ul in antibody stabilization buffer

-20 degree C for long term storage

ELISA (EIA), Western Blot (WB)

Dot Blot: 1:10,000. ELISA: 1:10,000. Western Blot: 1:500

Immunogen: Synthetic peptide corresponding to unique amino acid sequence on ILK 1/2 protein. Expression: Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.

Molecular Function: ATP binding, protein kinase binding, protein serine/threonine kinase activity, signal transducer activity. Subcellular Location: Cell junction, cell membrane, Peripheral membrane protein, Cytoplasmic side, cell projection

Primary Antibodies; Protein Kinases; Tyrosine Kinases; Integrin linked ILK Antibody

Affinity Purified Integrin-linked protein kinase Antibody. Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway.

9973397

Q13418.2

Q13418

36,467 Da

Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Bacterial Invasion Of Epithelial Cells Pathway (149807); Bacterial Invasion Of Epithelial Cells Pathway (148661); Cell Junction Organization Pathway (1270232); Cell-Cell Communication Pathway (1270231); Cell-extracellular Matrix Interactions Pathway (1270237); Endometrial Cancer Pathway (83109); Endometrial Cancer Pathway (521); Eukaryotic Transcription Initiation Pathway (198917)

This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

ILK: a tyrosine kinase-like kinase of the MLK family. Couples integrins and growth factors to downstream pathways involved in cell survival, cell cycle control, cell-cell adhesion and cell motility. Functions as a scaffold bridging the extra-cellular matrix and growth factor receptors to the actin cytoskeleton through interactions with the ILK-PINCH complex. This complex, which includes integrin, PINCH (which links ILK to receptor tyrosine kinases via Nck2), PARVA and affixin, is considered to be one of the convergence points of integrin- and growth factor-signaling pathways. May be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Stimulated downstream of PI3 kinase. Increased expression is correlated with progression of several tumor types, including breast, prostate, and colon carcinomas. Overexpression drives anchorage-independent growth and faster cell cycle. Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; EC 2.7.11.1; TKL group; MLK family; ILK subfamily. Chromosomal Location of Human Ortholog: 11p15.4. Cellular Component: cell junction; cell soma; costamere; cytoplasm; cytosol; dendritic shaft; extracellular matrix; focal adhesion; intercellular junction; lamellipodium; membrane; nucleoplasm; plasma membrane; protein complex; sarcomere; stress fiber; terminal button. Molecular Function: ATP binding; integrin binding; protein binding; protein kinase binding; protein serine/threonine kinase activity; SH3 domain binding; signal transducer activity. Biological Process: cell aging; cell cycle arrest; cell proliferation; cell-matrix adhesion; establishment and/or maintenance of epithelial cell polarity; fibril organization and biogenesis; integrin-mediated signaling pathway; myelin formation; myelination in the peripheral nervous system; negative regulation of neuron apoptosis; negative regulation of protein kinase activity; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; nerve development; neurite morphogenesis; peptidyl-serine phosphorylation; positive regulation of axon extension; positive regulation of BMP signaling pathway; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell-matrix adhesion; positive regulation of dendrite morphogenesis; positive regulation of MAP kinase activity; positive regulation of myoblast differentiation; positive regulation of osteoblast differentiation; positive regulation of phosphorylation; positive regulation of protein kinase B signaling cascade; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; protein heterooligomerization; protein kinase B signaling cascade; regulation of actin cytoskeleton organization and biogenesis; ureteric bud branching

0.1 mg Affinity-Purified

390 USD