Axl Antibody | MyBioSource MBS540006 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Axl Antibody

catalog :

MBS540006

quantity :

0.1 mg Affinity-Puri

price :

390 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS540006

products type :

Antibody

products full name :

Axl Antibody

products short name :

Axl

products name syn :

Adhesion related kinase; Ark; Tyro7; Tyrosine protein kinase receptor UFO antibody

other names :

tyrosine-protein kinase receptor UFO isoform 1; Tyrosine-protein kinase receptor UFO; tyrosine-protein kinase receptor UFO; AXL receptor tyrosine kinase; Adhesion-related kinase

other gene names :

Axl; Axl; Ark; Ufo; Tyro7; AI323647; Ark; Ufo

uniprot entry name :

UFO_MOUSE

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Monkey, Mouse, Rat

sequence length :

888

form :

Affinity Purified

concentration :

0.65 ug/ul in antibody stabilization buffer

storage stability :

-20 degree C for long term storage

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

Western Blot: 1:500

other info1 :

Immunogen: Synthetic peptide taken within amino acid region 840-880 on mouse AXL protein. The peptide was post translationally modified to acheive proper orientation and antigenicity. Expression: Developing tissues in late embryogenesis. In cells forming organ capsules as well as in connective tissue structures in adult.

other info2 :

Molecular Function: ATP-binding, Nucleotide binding, Kinase, Receptor, Transferase, Tyrosine-protein kinase, Immunity Differentation and Innate Immunity. Structure: Heterodimer and heterotetramer with ligand GAS6. Subcellular Location: Cell membrane; Single-pass type II membrane protein

products categories :

Primary Antibodies; Protein Kinases; Axl Antibody

products description :

Affinity Purified AXL receptor tyrosine kinase UFO isoform 1 Antibody. Receptor tyrosine kinase that transduces signals from the ECM into cytoplasm by binding growth factor GAS6. Regulates survival, proliferation, migration and differentiation.

ncbi gi num :

31542164

ncbi acc num :

NP_033491

ncbi gb acc num :

NM_009465.4

uniprot acc num :

Q00993

ncbi mol weight :

98,191 Da

ncbi pathways :

Signal Transduction Pathway (1366876); Signaling By VEGF Pathway (1366989); VEGFA-VEGFR2 Pathway (1366992)

uniprot summary :

AXL: a receptor tyrosine kinase that may function as a signal transducer between specific cell types of mesodermal origin. Interacts with SKP1. Overexpression in tissue culture causes oncogenic transformation. Overexpressed in several cancers including thyroid, ovarian, gastric, ER+ breast cancer and acute myeloid leukemia, where it is associated with poor prognosis. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Kinase, protein; Membrane protein, integral; EC 2.7.10.1; Protein kinase, TK; Oncoprotein; Protein kinase, tyrosine (receptor); TK group; Axl family. Cellular Component: cell surface; extracellular space; integral to membrane; membrane; plasma membrane. Molecular Function: ATP binding; kinase activity; myosin heavy chain binding; nucleotide binding; phosphatidylserine binding; phosphoinositide 3-kinase binding; protein heterodimerization activity; protein kinase activity; protein-tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity. Biological Process: apoptotic cell clearance; blood vessel remodeling; cell differentiation; cellular response to extracellular stimulus; entry of virus into host cell; enzyme linked receptor protein signaling pathway; erythrocyte homeostasis; forebrain cell migration; immune system process; inflammatory response; innate immune response; natural killer cell differentiation; negative regulation of apoptosis; negative regulation of interferon-gamma production; negative regulation of lymphocyte activation; negative regulation of neuron apoptosis; negative regulation of tumor necrosis factor production; neuron migration; ovulation cycle; peptidyl-tyrosine phosphorylation; phagocytosis; phosphorylation; platelet activation; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of natural killer cell differentiation; positive regulation of pinocytosis; positive regulation of protein kinase B signaling cascade; protein amino acid phosphorylation; protein kinase B signaling cascade; secretion by cell; spermatogenesis; vagina development

size1 :

0.1 mg Affinity-Purified

price1 :

390 USD

more info or order :

MyBioSource product webpage