PEDF protein | MyBioSource MBS539585 product information

product summary

request information :

company name :

MyBioSource

product type :

protein

product name :

PEDF protein

catalog :

MBS539585

quantity :

0.02 mg

price :

320 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS539585

products type :

Recombinant Protein

products full name :

PEDF protein

products short name :

PEDF

products name syn :

EPC-1 protein; SerpinF1 protein; Pigment epithelium-derived factor protein

other names :

pigment epithelium-derived factor; Pigment epithelium-derived factor; pigment epithelium-derived factor; serpin F1; cell proliferation-inducing gene 35 protein; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1; Cell proliferation-inducing gene 35 protein; EPC-1; Serpin F1

products gene name :

PEDF

other gene names :

SERPINF1; SERPINF1; OI6; OI12; PEDF; EPC-1; PIG35; PEDF; PEDF

uniprot entry name :

PEDF_HUMAN

host :

E.coli

reactivity :

Human

purity :

>90% pure by SDS PAGE and HPLC

form :

Supplied as a lyophilized powder

storage stability :

Store at 4 deg C until reconstitution. Following reconstitution aliquot and freeze at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

other info1 :

Residues: Region of PEDF protein corresponding to amino acids MQNPASPPEE GSPDPDSTGA LVEEEDPFFK VPVNKLAAAV SNFGYDLYRV RSSMSPTTNV LLSPLSVATA LSALSLGAEQ RTESIIHRAL YYDLISSPDI HGTYKELLDT VTAPQKNLKS ASRIVFEKKL RIKSSFVAPL EKSYGTRPRV LTGNPRLDLQ EINNWVQAQM KGKLARSTKE IPDEISILLL GVAHFKGQWV TKFDSRKTSL EDFYLDEERT VRVPMMSDPK AVLRYGLDSD LSCKIAQLPL TGSMSIIFFL PLKVTQNLTL IEESLTSEFI HDIDRELKTV QAVLTVPKLK LSYEGEVTKS LQEMKLQSLF DSPDFSKITG KPIKLTQVEH RAGFEWNEDG AGTTPSPGLQ PAHLTFPLDY HLNQPFIFVL RDTDTGALLF IGKILDPRGP

other info2 :

Endotoxin Level: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).

products categories :

Neuroscience; Proteins; Native & Recombinant Proteins; Recombinant

products description :

Purified recombinant Human PEDF protein. PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors such as VEGF and FGF2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins.

ncbi gi num :

39725934

ncbi acc num :

NP_002606.3

ncbi gb acc num :

NM_002615.5

uniprot acc num :

P36955

ncbi mol weight :

44.5 kDa

ncbi summary :

The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011]

uniprot summary :

Function: Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Ref.12 Ref.13. Subcellular location: Secreted. Melanosome. Note: Enriched in stage I melanosomes. Ref.16. Tissue specificity: Retinal pigment epithelial cells and blood plasma. Ref.10. Developmental stage: Expressed in quiescent cells. Domain: The N-terminal (AA 44-121) exhibits neurite outgrowth-inducing activity. The C-terminal exposed loop (AA 382-418) is essential for serpin activity. Post-translational modification: The N-terminus is blocked. Extracellular phosphorylation enhances antiangiogenic activity.N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan. Ref.15 Ref.17 Ref.18 Ref.20. Involvement in disease: Defects in SERPINF1 are the cause of osteogenesis imperfecta type 12 (OI12) [. MIM:613982]. OI12 is a connective tissue disorder characterized by bone fragility, low bone mass, and recurrent fractures. OI12 is characterized by features compatible with osteogenesis imperfecta type III in the Sillence classification. Patients have normal grayish sclerae and fractures of long bones and severe vertebral compression fractures, with resulting deformities observed as early as the first year of life. Ref.19. Sequence similarities: Belongs to the serpin family. Sequence caution: The sequence AAA84914.1 differs from that shown. Reason: Frameshift at position 356. The sequence AAA93524.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

size :

0.02 mg

price :

320 USD

more info or order :

MyBioSource product webpage