catalog number :
MBS539581
products type :
Recombinant Protein
products full name :
Sox2 protein
products short name :
[Sox2]
products name syn :
[Sox-2; Sox-2 protein; Sox 2 protein; Sex Determining Region Y- box 2 protein; Sox2; Sox 2]
other names :
[Sox2, partial; Sox2; Sox2]
products gene name :
[Sox2]
other gene names :
[Sox2]
uniprot entry name :
A4GU07_OREMO
sequence :
Region of Sox2 protein corresponding to amino acids MYNMMETELK PPGPQQTSGG GGGNSTAAAA GGNQKNSPDR VKRPMNAFMV WSRGQRRKMA QENPKMHNSE ISKRLGAEWK LLSETEKRPF IDEAKRLRAL HMKEHPDYKY RPRRKTKTLM KKDKYTLPGG LLAPGGNSMA SGVGVGAGLG AGVNQRMDSY AHMNGWSNGS YSMMQDQLGY PQHPGLNAHG AAQMQPMHRY DVSALQYNSM TSSQTYMNGS PTYSMSYSQQ GTPGMALGSM GSVVKSEASS SPPVVTSSSH SRAPCQAGDL RDMISMYLPG AEVPEPAAPS RLHMSQHYQS GPVPGTAING TLPLSHM.
purity :
> 95% by SDS-PAGE and HPLC analysis.
form :
Lyophilized from 10mM Sodium Acetate, pH 6.0 0.2u sterile filtered.
concentration :
25ug/vial;lyophilized
storage stability :
Ships ambient or refrigerated. Upon receipt store at -20 degree C. After reconstituted, can be stored at 4 degree C fo rup to 1 week. Working aliquots stored with a carrier protein are stable for at least 3 months at -20 degree C.
tested application :
User optimized
other info1 :
Grade: Recombinant Protein. Contaminants: Endotoxin level less than 0.1ng per ug. Protein Type: Recombinant. Biological Significance: Sox2, also known as sex determining region Y (SRY)-box 2, belongs to a diverse family of structurally-related transcription factors whose primary structure contains a 79-residue DNA-binding domain, called high mobility group (HMG) box. It plays an essential role in maintaining the pluripotency of embryonic stem cells (ESC) and determination of cell fate. Microarray analysis showed that Sox2 regulates the expression of multiple genes involved in embryonic development including FGF4, YES1 and ZFP206. Sox2 acts as a transcriptional activator after forming a ternary complex with Oct3/4 and a conserved non-coding DNA sequence (CNS1) located approximately 2 kb upstream of the RAX promoter. The introduction of Sox2, Oct4, Myc, and Klf4, into human dermal fibroblasts isolated from a skin biopsy of a healthy research fellow was sufficient to confer a pluripotent state upon the fibroblast genome. Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
other info2 :
Biohazard: Not for human use, use normal laboratory precautions when handling reagent. For research purposes only.
products categories :
DNA & RNA
products description :
Purified recombinant Human Sox2 protein
ncbi acc num :
ABO26872.1
ncbi mol weight :
34.3 kDa